Reduced reward processing in the brains of Parkinsonian patients
Reduced reward processing in the brains of Parkinsonian patients
复制标题
帕金森病患者大脑中的奖励处理减少
DOI：
10.1097/00001756-200011270-00019
复制
发表时间：
2000
期刊：
影响因子：
1.7
通讯作者：
W. Schultz
中科院分区：
文献类型：
--
作者：
G. Künig;K. Leenders;C. Martin;J. Missimer;Stefanie Magyar;W. Schultz
健康对照组和非痴呆、非抑郁帕金森病患者的局部脑血流量（rCBF）使用H215O PET测量，同时受试者进行预先学习的延迟反应模式识别任务。为了考察两组被试对奖励反应的差异，实验设计包括三种强化条件：无意义反馈的无强化、积极的象征性强化和金钱奖励。在对照组中，金钱奖励激活了双侧纹状体和前扣带回，以及单侧左侧小脑，中脑和内侧额回。符号强化显示了类似的激活模式，除了纹状体和左中脑没有激活。帕金森病患者对金钱奖励的反应是双侧小脑、内侧额回和前扣带回以及单侧右侧梭状回和中脑以及左侧尾状核和中央前回的激活增加。符号强化只在右侧小脑引起rCBF显著增加。与符号强化相比，金钱奖励引起颞顶联合皮层的延长激活。在对照组中观察到的模式表明了健康人脑中多巴胺能中脑边缘通路在奖赏处理中的作用，而帕金森病患者中的模式表明了患病大脑中补偿性皮质回路的参与。
Regional cerebral blood flow (rCBF) in healthy controls and non-demented, non-depressed Parkinsonian patients was measured using H215O PET while subjects performed a prelearned pattern recognition task with delayed response. To investigate differences between the two groups in response to reward, the experimental design consisted of three reinforcement conditions: no reinforcement consisting of nonsense feedback, positive symbolic reinforcement and monetary reward. In the controls, monetary reward activated bilaterally the striatum and anterior cingulate gyrus, as well as unilaterally the left cerebellum, midbrain and medial frontal gyrus. Symbolic reinforcement revealed a similar pattern of activation, except that the striatum and left midbrain showed no activation. The Parkinsonian patients responded to monetary reward with increased activation bilaterally in the cerebellum, medial frontal gyrus, and anterior cingulate gyrus as well as unilaterally in the right fusiform gyrus and midbrain and left caudate nucleus and precentral gyrus. Symbolic reinforcement induced significantly increased rCBF in the right cerebellum only. Compared with symbolic reinforcement, monetary reward produced extended activation of temporoparietal association cortex. The pattern observed in the controls demonstrates the role in reward processing of dopaminergic mesolimbic pathways in the healthy human brain, whereas the pattern in the Parkinsonian patients suggests the involvement of compensatory cortical loops in the diseased brain.