Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes.
Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes.
复制标题
DOI：
10.2174/187231207779814355
复制
发表时间：
2007-01-01
影响因子：
--
通讯作者：
Yamazaki, Hiroshi
中科院分区：
文献类型：
--
作者：
Shimizu, Makiko;Matsumoto, Yoshiaki;Yamazaki, Hiroshi
To prevent rapid forming O-glucuronide of propofol (2,6-diisopropylphenol), an intravenous anesthetic, effects of propofol analogs were investigated. Propofol was predominately glucuronidated by human UGT1A9 and intestinal or liver microsomes. 2,5-Diisopropylphenol inhibited the propofol glucuronidation. A possibility of developing orally administrable agents or of reducing propofol dose by coadministration is suggested.
