Copper(I)-Catalyzed Stereo- and Chemoselective Borylative Radical Cyclization of Alkyl Halides Bearing an Alkene Moiety
Copper(I)-Catalyzed Stereo- and Chemoselective Borylative Radical Cyclization of Alkyl Halides Bearing an Alkene Moiety
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DOI：
10.1021/acs.orglett.7b00940
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发表时间：
2017-05-19
期刊：
影响因子：
5.2
通讯作者：
Ito, Hajime
中科院分区：
文献类型：
--
作者：
Iwamoto, Hiroaki;Akiyama, Sota;Ito, Hajime
研究了含烯烃的卤代烷在铜（I）/二硼催化体系下的立体选择性硼化自由基环化反应。优化的反应条件使我们能够控制烯丙基取代和硼化自由基环化之间的化学选择性。硼化产物随后通过新形成的C-B键的衍生化转化为高度官能化的有机化合物。这种硼化自由基环化反应为化合物的合成提供了一种新的方法。各种杂环化合物的立体选择性合成。
The stereoselective borylative radical cyclization of alkyl halides containing an alkene moiety was developed using a copper(I)/diboron catalyst system. The optimized reaction conditions allowed us to control the chemoselectivity between the allylic substitution and the borylative radical cyclization. The borylation products were subsequently converted to highly functionalized organic compounds by derivatization of the newly formed C-B bond. This borylative radical cyclization offers a novel methodology for compounds. the stereoselective synthesis of various heterocyclic compounds.