Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications
Genetic association of hypoxia inducible factor 1-alpha (HIF1A) Pro582Ser polymorphism with risk of diabetes and diabetic complications
复制标题
缺氧诱导因子 1-α (HIF1A) Pro582Ser 多态性与糖尿病和糖尿病并发症风险的遗传关联
DOI：
10.18632/aging.103213
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Zhang Wei
中科院分区：
文献类型：
--
作者：
Ren Huan;Luo Jian-Quan;Gao Yong-Chao;Chen Man-Yun;Chen Xiao-Ping;Zhou Hong-Hao;Jiang Ying;Zhang Wei
糖尿病是一种与年龄相关的慢性疾病，伴有多种并发症，是全球发病率和死亡率的主要原因之一。一些研究表明，缺氧诱导因子1-α（HIF 1A）基因多态性可能与糖尿病和糖尿病并发症有关。然而，这种关联仍然模糊不清。因此，我们进行了荟萃分析，以提供关于该问题的更准确的结论。采用比值比（OR）和相应的95%置信区间（CI）评估相关性的强度。在杂合子遗传模型下，HIF 1A Pro582 Ser多态性与糖尿病的发生有保护性关系（OR = 0.70，95%CI = 0.55-0.91; P = 0.007）。在糖尿病并发症风险中观察到类似的关联，（OR = 0.69，95%CI = 0.57-0.83; P < 0.001），纯合子（OR = 0.51，95% CI = 0.30-0.87; P = 0.014）、隐性（OR = 0.73，95% CI = 0.59-0.90; P = 0.004）和显性（OR = 0.40，95% CI = 0.25-0.65; P < 0.001）遗传模型。未发现HIF 1A Ala 588 Thr多态性对糖尿病和糖尿病并发症的风险有影响。总之，这些发现揭示了HIF 1A Pro582 Ser多态性对糖尿病和糖尿病并发症的保护作用。
Diabetes is an age-related chronic disease associated with a number of complications, emerging as one of the major causes of morbidity and mortality worldwide. Several studies indicated that hypoxia-inducible factor 1-alpha (HIF1A) genetic polymorphisms may be associated with diabetes and diabetic complications. However, this association remains ambiguous. Thus, we performed a meta-analysis to provide more precise conclusion on this issue. Odds ratios (OR) with corresponding 95% confidence intervals (CI) were applied to assess the strength of the relationships. There was a protective association between HIF1A Pro582Ser polymorphism and diabetes under the heterozygous genetic model (OR = 0.70, 95% CI = 0.55-0.91; P = 0.007). Similar associations were observed in diabetic complications risk under the allelic (OR = 0.69, 95% CI = 0.57-0.83; P < 0.001), homozygous (OR = 0.51, 95% CI = 0.30-0.87; P = 0.014), recessive (OR = 0.73, 95% CI = 0.59-0.90; P = 0.004) and dominant (OR = 0.40, 95% CI = 0.25-0.65; P < 0.001) genetic models. No effects of the HIF1A Ala588Thr polymorphism were found in risk of diabetes and diabetic complications. Taken together, these findings revealed the protective effect of HIF1A Pro582Ser polymorphism against diabetes and diabetic complications.