Attempts to transmit visceral leishmaniasis to man
Attempts to transmit visceral leishmaniasis to man
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DOI：
10.1016/s0035-9203(40)90043-8
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发表时间：
1940-01-01
期刊：
影响因子：
--
通讯作者：
ADLER, S.
中科院分区：
文献类型：
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作者：
ADLER, S.
内脏利什曼病以前从未通过实验传播给人类。来自东方疮的热带利什曼原虫现在首次被报道为通过从人类病变处接种而直接传播。L. donovani（印度血统）也被报道在一个例子中成功地从培养物中接种到人身上。在这种情况下，病人患有无法治愈的胃癌。在类似条件下的其他尝试完全失败。尽管寄生虫感染非常严重，但黑热病的临床症状完全消失。在癌症死亡后，对微观和宏观病理状况进行了仔细检查，并提供了详细信息。作者认为，鞭毛虫通过白蛉的通道使它们对人类血清免疫，否则，人类血清几乎可以完美地抵御鞭毛虫在人与人之间的直接转移。如果鞭毛虫通过血清屏障，它们会被改造，以至于它们可能存在，甚至可能大量存在，但不能产生临床黑热病，因此，过去由于未能检查尸体病理学迹象以确定病菌的存在，许多直接传播的病例被遗漏。|| 摘要：A. C.沃尔顿
Visceral leishmaniasis has never before been experimentally transmitted to man. Leishmania tropica from oriental sores is now reported for the first time as being directly transmitted by inoculation from human lesions. L. donovani (of Indian origin) is also reported as being successfully inoculated from culture into man in one instance. In this case the patient was suffering from incurable carcinoma of the stomach. Other attempts under similar conditions were complete failures. Clinical symptoms of kala-azar were completely absent in spite of an extremely heavy parasite infection. Following death from the cancer, a careful examination of both micro- and macroscopic pathological conditions was made and the details are presented. The author suggests that the passage of the flagellates through the sandfly makes them immune to human serum that otherwise acts as an almost perfect defense against the direct transfer of the flagellates from man to man. If the flagellates pass the serum barrier, they are so modified that they may exist, perhaps even in great numbers, but are unable to produce clinical kala-azar, and hence many cases of direct transmission have been missed in the past because of failure to check for the post-mortem pathological indications of the presence of the organisms. || ABSTRACT AUTHORS: A. C. Walton