Determinants of salivary cotinine levels among current smokers in Mexico
Determinants of salivary cotinine levels among current smokers in Mexico
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DOI：
10.1080/14622200412331324956
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发表时间：
2004-12-01
影响因子：
4.7
通讯作者：
Samet, JM
中科院分区：
文献类型：
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作者：
Campuzano, JC;Hernandez-Avila, M;Samet, JM
本研究描述了墨西哥吸烟者的唾液可替宁水平及其与每天吸烟的关系。使用基于每天香烟数量的抽样策略，我们在1999年期间从墨西哥城和墨西哥的莫雷洛斯州招募了1222名吸烟者。吸烟行为和其他已知影响尼古丁摄入量和可替宁水平的因素在一次访谈中使用标准化问卷进行了确定。采用毛细管气相色谱-氮磷检测法测定唾液中的可替宁。我们使用广义加性模型来描述唾液可替宁水平和感兴趣变量之间的关系。人群的平均年龄为39.7岁(SD=15.6岁)，平均可替宁水平为194.7 ng/ml(SD=134.8；范围为10.1~767)。参与者平均每天吸烟15.5支(SD=11.3)。唾液中的可替宁与每天吸烟的香烟呈正相关，尽管这种关联不是线性的。每天抽20支以上的香烟。在调整了每天吸烟的因素后，我们发现可替宁水平的显著预测因素包括年龄、体重指数、香烟生产商和吸烟行为变量。这些结果可能会对墨西哥吸烟者服用尼古丁药物以帮助戒烟产生影响，并表明香烟是贴上淡香烟还是普通香烟的标签与吸烟所产生的尼古丁剂量没有关系。
The present study describes salivary cotinine levels and their relationship to cigarettes smoked per day in Mexican smokers. Using a sampling strategy based on the number of cigarettes per day, we recruited 1,222 smokers from Mexico City and the state of Morelos in Mexico during 1999. Smoking behaviors and other factors known to affect nicotine intake and cotinine level were identified in an interview using a standardized questionnaire. Salivary cotinine was measured by capillary gas chromatography with nitrogen-phosphorus detection. We used generalized additive models to describe the relationship between salivary cotinine levels and variables of interest. The mean age of the population was 39.7 years (SD = 15.6 years), with a mean cotinine level of 194.7 ng/ml (SD = 134.8; range = 10.1-767). Participants smoked a mean of 15.5 cigarettes per day (SD = 11.3). Salivary cotinine and cigarettes smoked per day were positively related, although the association was not linear. flattening above 20 cigarettes per day. After adjusting for cigarettes per day, we found that significant predictors of cotinine levels included age, body mass index, cigarette producer, and smoking behavior variables. These results may have, implications for dosing with nicotine medications to aid smoking cessation in Mexican smokers and suggest that whether the cigarette is labeled light or regular has no relationship to nicotine dose from smoking cigarettes.