A novel high-strength poly(ionic liquid)/PVA hydrogel dressing for antibacterial applications
A novel high-strength poly(ionic liquid)/PVA hydrogel dressing for antibacterial applications
复制标题
一种用于抗菌应用的新型高强度聚（离子液体）/PVA 水凝胶敷料
DOI：
10.1016/j.cej.2019.02.030
复制
发表时间：
2019-06-01
影响因子：
15.1
通讯作者：
Li, Yao
中科院分区：
文献类型：
--
作者：
Fang, Huan;Wang, Jihui;Li, Yao
抗菌伤口敷料在伤口愈合和感染治疗中起着重要作用。然而，传统的抗菌伤口敷料通过被动扩散不可控地释放抗生素或银离子。抗生素和银离子的过度使用可能导致耐药性、副作用以及银质沉着病，从而阻碍愈合过程并产生其他健康危害。为了克服这些缺点，本文报道了一种通过化学聚合和物理交联合成高强度、不释放抗菌剂的聚（离子液体）/聚乙烯醇水凝胶敷料的简便方法。该水凝胶敷料对细菌（大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌）、真菌（白色念珠菌）以及霉菌（黑曲霉、米曲霉和根霉）表现出有效的抗菌能力。此外，在小鼠模型中，该水凝胶敷料有效地加速了皮肤伤口的愈合。在愈合15天后，组织学检测表明，这种水凝胶敷料比对照组能更快地促进完整表皮的重建。因此，这种聚（离子液体）/聚乙烯醇水凝胶有作为抗菌伤口愈合敷料的潜力。
Antibacterial wound dressings play an important role in wound healing and infection treatment. However, traditional antibacterial wound dressings uncontrollably release antibiotics or silver ions through passive diffusion. The overuse of antibiotics and silver ions may cause drug resistance, side effects, and argyrism, thereby hindering the healing process and creating other health hazards. To overcome these shortcomings, this paper reports an easy approach to synthesize non-releasing antimicrobial Poly(ionic liquid)/PVA hydrogel dressing with high-strength through chemical polymerization and physical cross-linking. The hydrogel dressing exhibited effective antibacterial ability against bacteria (E. coli, S. aureus and B. subtilis), fungus (C. albicans), and mold (Asp. niger, Asp. oryzae, and Rhizopus). Furthermore, in a murine model, the hydrogel dressing efficiently accelerated cutaneous wound healing. After 15 days of healing process, histological tests indicated that this hydrogel dressing can promote the reconstruction of intact epidermis faster than the control. Therefore, this Poly (ionic liquid)/PVA hydrogel has potential as an antibacterial wound-healing dressing.