COMPARISON OF ACTIONS OF THROMBIN AND THROMBIN-LIKE VENOM ENZYMES ANCROD AND BATROXOBIN
COMPARISON OF ACTIONS OF THROMBIN AND THROMBIN-LIKE VENOM ENZYMES ANCROD AND BATROXOBIN
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DOI：
10.1055/s-0038-1648004
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发表时间：
1976-01-01
影响因子：
6.7
通讯作者：
ARONSON, DL
中科院分区：
文献类型：
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作者：
ARONSON, DL
凝血酶作用于几种凝血蛋白，产生具有生理、药理和病理潜力的产物。最敏感的凝血酶底物似乎是因子VIII。在体外研究的一些凝血酶依赖性反应和建议作为对照反应似乎对凝血酶的作用太不敏感，在体内的意义。类凝血酶毒液酶Ancrod [来自红口蝮蛇]和Batroxobin [来自Bothrops atrox]与凝血酶的唯一共同酶反应是去除纤维蛋白肽A。
Thrombin acts on several coagulant proteins to produce products with physiologic, pharmacologic and pathologic potential. The most sensitive thrombin substrate seems to be factor VIII. Some thrombin dependent reactions studied in vitro and proposed as control reactions seem too insensitive to the action of thrombin to be of in vivo significance. The only enzymic reaction the thrombin-like venom enzymes, Ancrod [from Agkistrodon rhodostoma] and Batroxobin [from Bothrops atrox], have in common with thrombin is the removal of fibrinopeptide A.