PROTEIN, CARBOHYDRATE, AND ETHANOL-CONSUMPTION - INTERACTIONS IN AA AND ANA RATS
PROTEIN, CARBOHYDRATE, AND ETHANOL-CONSUMPTION - INTERACTIONS IN AA AND ANA RATS
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DOI：
10.1016/0741-8329(88)90058-4
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发表时间：
1988-05-01
期刊：
影响因子：
2.3
通讯作者：
SINCLAIR, JD
中科院分区：
文献类型：
--
作者：
FORSANDER, OA;SINCLAIR, JD
酒精偏好AA系的雌性大鼠在蛋白质、碳水化合物和脂肪来源之间进行选择。随后自由饮酒减少了他们对碳水化合物的摄入，但对蛋白质或脂肪没有影响。个体酒精摄入量与碳水化合物摄入量（-0.76）和酒精引起的碳水化合物摄入量变化（-0.83）呈负相关，但与同期蛋白质摄入量（0.78）呈正相关。随后发现AA大鼠的酒精消耗量和乙醇消除率直接随预混合饮食的蛋白质含量（5%、10%、20%和40%能量）而变化--他们在40%的蛋白质饮食上喝的乙醇是5%蛋白质饮食的9倍多--但避免饮酒的ANA大鼠不受蛋白质摄入的影响。结果清楚地表明，三种常量营养素以不同的方式与酒精消耗有关，表明蛋白质摄入量通过与乙醇消除相关的因素影响AA大鼠对酒精的选择（但不是通过消除速率的天花板效应），酒精反过来又减少了碳水化合物的消耗。
Female rats of the alcohol-preferring AA line were given a choice between protein, carbohydrate, and fat sources. Subsequent free access to alcohol decreased their intake of carbohydrate but not of protein or fat. The individual alcohol intakes were negatively correlated with the carbohydrate intakes (-0.76) and with the alcohol-induced changes in carbohydrate intake (-0.83), but positively correlated with the concurrent protein intakes (0.78). The alcohol consumption and ethanol elimination rate of AA rats were subsequently found to vary directly with the protein content (5, 10, 20 and 40% by energy) of the premixed diet given to them-they drank more than 9 times more ethanol on the 40% than onthe 5% protein diet-but he alcohol-avoiding ANA rats was not affected by protein intake. The results clearly indicate that the three macronutrients ae related to alcohol consumption in different ways, suggesting that protein intake affects the selection of alcohol of AA rats through a factor correlated to ethanol elimination (but not through a ceiling effect fromthe rate of elimination) and that the alcohol in turn reduces corbohydrate consumption.