The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study.
The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study.
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DOI：
10.1164/arrd.1987.135.6.1255
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发表时间：
1987-06
期刊：
影响因子：
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通讯作者：
D. Sparrow;G. O'Connor;T. Colton;C. Barry;S. Weiss
中科院分区：
文献类型：
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作者：
D. Sparrow;G. O'Connor;T. Colton;C. Barry;S. Weiss
标准老龄化研究的458名男性参与者通过简化的乙酰甲胆碱激发试验评估了非特异性支气管反应性，他们还完成了呼吸问卷和肺活量测定。对乙酰甲胆碱激发试验的阳性反应被定义为在试验期间FEV1下降大于或等于20%。吸烟与乙酰甲胆碱阳性反应显著相关(p<0.001)。Logistic回归分析表明，在考虑吸烟状况和年龄后，对乙酰甲胆碱的阳性反应与任何喘息(p=0.002)和持续性喘息(p<0.001)均有显著关联；反应性与慢性咳嗽之间的关联具有边缘意义(p=0.06)。多元线性回归分析显示乙酰甲胆碱应答阳性与较低的FEV1(p<0.001)和FEF25-75(p<0.001)独立相关。使用剂量-反应斜率的对数而不是二分变量来表征应答者的状态在线性模型和Logistic模型中产生了非常相似的结果。这项横断面研究的结果表明，非特异性反应性水平的提高与成年男性的喘息和咳嗽症状以及肺功能水平的下降显著相关。对这些男性的纵向随访应能阐明非特异性反应性作为慢性阻塞性肺疾病后续发展的危险因素的重要性。
Nonspecific bronchial responsiveness was assessed by an abbreviated methacholine challenge test in 458 male participants of the Normative Aging Study, who also completed a respiratory questionnaire and spirometry. A positive response to the methacholine challenge test was defined as a greater than or equal to 20% decline in FEV1 during the test. Cigarette smoking was significantly associated with a positive methacholine response (p less than 0.001). Logistic regression analyses indicated that there was a significant association between a positive response to methacholine and both any wheeze (p = 0.002) and persistent wheeze (p less than 0.001) after taking into account smoking status and age; an association between responsiveness and chronic cough was of borderline significance (p = 0.06). Multiple linear regression analyses indicated that positive methacholine responsiveness was independently associated with lower levels of FEV1 (p less than 0.001) and FEF25-75 (p less than 0.001). Using the log of the dose-response slope rather than a dichotomous variable to characterize responder status yielded very similar results in the linear and logistic models. The findings of this cross-sectional study suggest that increased level of nonspecific responsiveness is significantly associated with wheeze and cough symptoms and decreased levels of pulmonary function in adult men. Longitudinal follow-up of these men should shed light on the importance of nonspecific responsiveness as a risk factor for the subsequent development of chronic obstructive pulmonary disease.