Trends in Human Papillomavirus-Associated Cancers - United States, 1999-2015.
Trends in Human Papillomavirus-Associated Cancers - United States, 1999-2015.
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DOI：
10.15585/mmwr.mm6733a2
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发表时间：
2018-08-24
期刊：
影响因子：
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通讯作者：
Benard VB
中科院分区：
文献类型：
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作者：
Van Dyne EA;Henley SJ;Saraiya M;Thomas CC;Markowitz LE;Benard VB
人乳头瘤病毒 (HPV) 是宫颈癌以及一些口咽癌、外阴癌、阴道癌、阴茎癌和肛门癌的已知病因。为了评估 1999 年至 2015 年间 HPV 相关癌症发病率的趋势（以平均年百分比变化 (AAPC) 为特征），CDC 分析了覆盖美国 97.8% 人口的癌症登记处的数据。 1999 年总共报告了 30,115 例 HPV 相关癌症新病例，2015 年报告了 43,371 例。1999 年至 2015 年期间，宫颈癌发病率每年下降 1.6%；阴道鳞状细胞癌 (SCC) 发病率每年下降 0.6%；男性（2.7%）和女性（0.8%）的口咽部鳞状细胞癌发病率均有所增加；男性（2.1%）和女性（2.9%）的肛门鳞状细胞癌发病率也有所增加；外阴鳞状细胞癌发生率增加（1.3%）；阴茎 SCC 率保持稳定。 2015 年，口咽部鳞状细胞癌（男性 15,479 例，女性 3,438 例）是最常见的 HPV 相关癌症。通过高质量的癌症登记进行持续监测对于监测癌症发病率和这些潜在可预防癌症的趋势非常重要。
Human papillomavirus (HPV) is a known cause of cervical cancer, as well as some oropharyngeal, vulvar, vaginal, penile, and anal cancers. To assess trends, characterized by average annual percent change (AAPC), in HPV-associated cancer incidence during 1999–2015, CDC analyzed data from cancer registries covering 97.8% of the U.S. population. A total of 30,115 new cases of HPV-associated cancers were reported in 1999 and 43,371 in 2015. During 1999–2015, cervical cancer rates decreased 1.6% per year; vaginal squamous cell carcinoma (SCC) rates decreased 0.6% per year; oropharyngeal SCC rates increased among both men (2.7%) and women (0.8%); anal SCC rates also increased among both men (2.1%) and women (2.9%); vulvar SCC rates increased (1.3%); and penile SCC rates remained stable. In 2015 oropharyngeal SCC (15,479 cases among men and 3,438 among women) was the most common HPV-associated cancer. Continued surveillance through high-quality cancer registries is important to monitor cancer incidence and trends in these potentially preventable cancers.