CROSSBRIDGE BEHAVIOR DURING MUSCLE-CONTRACTION
CROSSBRIDGE BEHAVIOR DURING MUSCLE-CONTRACTION
复制标题
DOI：
10.1007/bf00713057
复制
发表时间：
1985-01-01
影响因子：
2.7
通讯作者：
KRESS, M
中科院分区：
文献类型：
--
作者：
HUXLEY, HE;KRESS, M
最近用探针和X射线方法观察到的一些交叉桥梁在收缩过程中的行为被认为与这一过程的能量学有关。结果表明，只要横桥行程的张力产生部分只有40？左右，即通常可接受的值的三分之一左右，就可以获得与这些观测结果相一致的、涉及强连接和弱连接的横桥周期的自洽图像。在产生张力的桥梁中，肌球蛋白头部亚单位可能具有接近于刚性的结构。建议了这样一种机制，即这样的系统在快速释放后仍可产生高达120？的快速张力恢复。
A number of recent observations by probe and X-ray methods on the behaviour of crossbridges during contraction is considered in relation to the energetics of the process. It is shown that a self-consistent picture of the crossbridge cycle, compatible with these observations and involving strongly and weakly attached crossbridges, can be obtained providing that the tension-generating part of the crossbridge stroke is only about 40 Å i.e. about one-third of the usually accepted value. The myosin head subunits in the tension-generating bridges could have a configuration close to that of rigor. A mechanism is suggested whereby rapid tension recovery after quick releases up to 120 Å could still be produced by such a system.