The deficit syndrome in the DSM-IV field trial .1. Alcohol and other drug abuse
The deficit syndrome in the DSM-IV field trial .1. Alcohol and other drug abuse
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DOI：
10.1016/0920-9964(95)00102-6
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发表时间：
1996-05-01
影响因子：
4.5
通讯作者：
McGlashan, T
中科院分区：
文献类型：
--
作者：
Kirkpatrick, B;Amador, XF;McGlashan, T
药物滥用在精神分裂症中很常见。以前的研究表明，与没有缺陷特征的患者相比，缺陷综合征患者滥用药物的风险较低。我们在DSM-IV现场试验数据集中区分了缺陷和非缺陷组，并比较了两组相对于酒精，大麻和其他药物滥用的当前和终身（有史以来最严重的）严重程度。缺陷综合征患者目前使用酒精和其他药物的严重程度较低，但两组相对于大麻使用没有显着差异。缺陷患者也有较轻的终身使用所有三类药物。这些发现不能归因于缺陷组和非缺陷组在人口统计学、精神病症状的严重程度、疾病的慢性程度或两组可用信息的质量方面的差异。缺陷分类和药物滥用与功能水平差独立相关。广义上的阴性症状比缺陷/非缺陷分类更弱的药物滥用预测因子。这些发现进一步支持了精神分裂症缺陷综合征的有效性。在精神分裂症中，可以确定药物滥用风险相对较高或较低的群体。
Drug abuse is common in schizophrenia. Previous studies suggested patients with the deficit syndrome have a lower risk of drug abuse than do patients without deficit features. We distinguished deficit and nondeficit groups in the DSM-IV Field Trial dataset, and compared the two groups relative to current and lifetime (worst ever) severity of alcohol, cannabis, and other drugs of abuse. Deficit syndrome patients had a lower severity of current use of alcohol and other drugs, but the two groups did not differ significantly relative to cannabis use. Deficit patients also had less severe Lifetime use of all three classes of drugs. These findings could not be attributed to differences between the deficit and nondeficit groups in demographics, severity of psychotic symptoms, chronicity of illness, or the quality of information available for the two groups. Deficit categorization and drug abuse were independently associated with poor level of function. Negative symptoms broadly defined were weaker predictors of drug abuse than was the deficit/nondeficit categorization. These findings further support the validity of the deficit syndrome of schizophrenia. Within schizophrenia, groups with relatively high or low risk for substance abuse can be identified.