Partitioning of polychlorinated biphenyls and hexachlorobenzene into human faeces
Partitioning of polychlorinated biphenyls and hexachlorobenzene into human faeces
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DOI：
10.1016/s0045-6535(01)00100-x
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发表时间：
2002-01-01
期刊：
影响因子：
8.8
通讯作者：
McLachlan, MS
中科院分区：
文献类型：
--
作者：
Moser, GA;McLachlan, MS
人体持久性亲脂性有机污染物（PLOP）的膳食吸收被认为是通过消化道内腔和壁之间的化学物质分配发生的。因此，管腔内容物的分配特性是控制吸收的关键因素。本研究测定了11种多氯联苯和六氯苯在粪便中的分配特性。四名志愿者参与了这项研究，他们每个人都提供了正常饮食和素食饮食的粪便。粪便/气体平衡分配系数K-FG在不同化合物之间变化超过三个数量级。logK（FG）和logK（OA）之间的线性关系，辛醇/空气分配系数，观察到。该关系的斜率> 1，表明粪便的溶剂性质比辛醇的极性小。对于给定的化合物，KFG在正常饮食的个体之间的变化高达2.8倍。素食对KFG的影响对于两名志愿者来说是微不足道的，他们只是从正常饮食中删除了鱼类和动物产品，但KFG平均增加了2倍，这两个人在素食中增加了不易消化的全谷物和蔬菜的消费。在K-FG的基础上计算粪便中的逸度。发现它们远低于血液中的逸度。据推测，这是由于空肠壁中的逸度暂时降低，这是由膳食脂质的吸收引起的，导致管腔内容物和消化道壁之间的平衡，逸度低于血液和身体其他部分中存在的逸度。(C)2002爱思唯尔科技有限公司。保留所有权利。
The dietary absorption of persistent lipophilic organic pollutants (PLOPs) in humans is believed to occur via partitioning of the chemical between the lumen and the wall of the digestive tract. As such, the partitioning properties of the lumen contents are a key factor governing absorption. In this study, the partitioning properties of faeces were measured for 11 polychlorinated biphenyls and hexachloro, benzene (HCB). Four volunteers participated in the study, each of them providing faeces from a normal diet and a vegetarian diet. The faeces/gas equilibrium partition coefficient K-FG varied by over three orders of magnitude between the different compounds. A linear relationship between logK(FG) and logK(OA), the octanol/air partition coefficient, was observed. The slope of the relationship was > 1, indicating that the solvent properties of faeces were less polar than those of octanol. For a given compound, KFG varied up to a factor of 2.8 between the individuals on a normal diet. The influence of the vegetarian diet on KFG was negligible for the two volunteers who simply deleted fish and animal products from their normal diet, but KFG increased on average by a factor of 2 in the two individuals who increased their consumption of less readily digestible whole grains and vegetables in their vegetarian diet. On the basis of K-FG, the fugacities in the faeces were calculated. They were found to be much lower than the fugacities in blood. It is hypothesised that this is due to a temporary decrease in the fugacity in the wall of the jejunum caused by absorption of dietary lipids that results in equilibration between the lumen contents and the wall of the digestive tract at a fugacity below that present in the blood and the rest of the body. (C) 2002 Elsevier Science Ltd. All rights reserved.