Avian heterophils in inflammation and disease resistance
Avian heterophils in inflammation and disease resistance
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DOI：
10.1093/ps/77.7.972
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发表时间：
1998-07-01
期刊：
影响因子：
4.4
通讯作者：
Harmon, BG
中科院分区：
文献类型：
--
作者：
Harmon, BG
异嗜细胞是鸡类鸟类急性炎症反应中的主要颗粒白细胞。异嗜细胞具有高度吞噬能力，并且具有广谱抗菌活性。它们在发炎组织中积聚，造成组织损伤并形成形态与爬行动物炎症病变相似的异嗜性肉芽肿。禽异嗜性细胞缺乏髓过氧化物酶，主要依靠非氧化机制发挥抗菌活性。在异嗜颗粒中发现的β-防御素可以杀死多种细菌病原体，并且是异嗜抗菌库的主要组成部分。异嗜细胞形成细胞防御的第一道防线，抵抗肺部和气囊中入侵的微生物病原体，而肺部和气囊缺乏常驻巨噬细胞。
Heterophils are the predominate granulated leukocyte in the acute inflammatory response in gallinaceous birds. Heterophils are highly phagocytic and are capable of a broad spectrum of antimicrobial activity. They accumulate in inflamed tissue, causing tissue damage and forming heterophil granulomas that are morphologically similar to inflammatory lesions in reptiles. The avian heterophil lacks myeloperoxidase and depends primarily on nonoxidative mechanisms for antimicrobial activity. The beta-defensins found in heterophil granules can kill a wide variety of bacterial pathogens and are a major component of the heterophil antimicrobial arsenal. Heterophils form the first Line of cellular defense against invading microbial pathogens in the lungs and air sacs where resident macrophages are lacking.