Sex differences in connectivity of the subgenual anterior cingulate cortex
Sex differences in connectivity of the subgenual anterior cingulate cortex
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DOI：
10.1016/j.pain.2014.01.005
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发表时间：
2014-04-01
期刊：
影响因子：
7.4
通讯作者：
Davis, Karen D.
中科院分区：
文献类型：
--
作者：
Wang, Gang;Erpelding, Nathalie;Davis, Karen D.
我们以前报道过，女性表现出更大的热痛适应长期的疼痛刺激和更大的习惯性重复疼痛刺激比男性。这种性别差异背后的神经机制尚不清楚。然而，Bingel等人（2007）已经表明，每天疼痛测试8天后的疼痛习惯与膝下前扣带皮层（sgACC）的疼痛诱发活动增加相关，表明疼痛习惯可能通过sgACC和下行疼痛抗伤害感受系统之间的连接介导。因此，我们研究了与男性相比，女性在sgACC和下行抗伤害感受系统之间是否具有更强的功能连接性（FC）和更大的结构连接性（SC）。我们的分析显示：1）女性sgACC与中脑导水管周围灰质（PAG）、中缝核、内侧丘脑和前中扣带皮层（aMCC）之间的FC比男性大; 2）男性sgACC与前丘脑和颞顶交界处的FC比女性强; 3）女性和男性sgACC与PAG、丘脑、aMCC、前丘脑和杏仁核之间的SC相似;（4）男性与下丘脑的sgACC SC比女性强。这些数据表明，女性的脑回路可能会提供更大的参与下行调制系统介导的疼痛习惯。相比之下，在男性中，显着性网络可能更活跃，这可以支持对疼痛的持续关注，从而防止疼痛习惯化。此外，下丘脑的研究结果表明，男性比女性有更强大的压力和内啡肽系统。(C)2014年国际疼痛研究协会。Elsevier B. V.出版，保留所有权利。
We previously reported that women exhibit greater heat pain adaptation to a prolonged painful stimulus and greater habituation to repeated painful stimuli than men. The neural mechanism underlying this sex difference is unknown. However, Bingel et al. (2007) have shown that pain habituation after 8 days of daily pain testing is associated with an increase in pain-evoked activity of the subgenual anterior cingulate cortex (sgACC), suggesting that pain habituation may be mediated via connectivity between the sgACC and the descending pain antinociceptive system. Therefore, we investigated whether women have stronger functional connectivity (FC) and greater structural connectivity (SC) compared to men between the sgACC and the descending antinociceptive system. Our analyses revealed that 1) women exhibited greater FC between the sgACC and the periaqueductal gray (PAG), raphe nucleus, medial thalamus, and anterior midcingulate cortex (aMCC) than men; 2) men had stronger sgACC FC with the anterior insula and temporoparietal junction than women; 3) women and men exhibited comparable SC of the sgACC with the PAG, thalamus, aMCC, anterior insula, and amygdala; and 4) men have stronger sgACC SC with the hypothalamus than women. These data indicate that brain circuitry in women may provide for greater engagement of the descending modulation system mediating pain habituation. In contrast, in men, the salience network may be more engaged, which could support greater sustained attention to pain, thereby preventing pain habituation. Furthermore, the hypothalamus findings suggest a more powerful stress and endorphin-based system at play in men than women. (C) 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.