Novel hybrid optical sensor materials for in-breath O2 analysis
Novel hybrid optical sensor materials for in-breath O2 analysis
复制标题
DOI：
10.1039/b716197b
复制
发表时间：
2008-01-01
期刊：
影响因子：
4.2
通讯作者：
McDonagh, Colette
中科院分区：
文献类型：
--
作者：
Higgins, Clare;Wencel, Dorota;McDonagh, Colette
本研究的重点是优化和表征的新型，有机改性硅酸盐（ORMOSIL）为基础的，混合传感器膜用于检测O-2的呼吸呼吸的基础上，在人类健康监测应用。传感原理是基于O-2-敏感的钌配合物[Ru（II）-三（4，7-二苯基-1，10-菲咯啉）]的发光猝灭，它已被困在多孔溶胶-凝胶膜。所采用的检测方法是使用蓝色LED激发和光电二极管检测的相位荧光法。候选传感器膜包括基于有机硅前体、甲基三乙氧基硅烷、乙基三乙氧基硅烷、正丙基三乙氧基硅烷和苯基三乙氧基硅烷的那些。虽然作者先前已经确定这些薄膜对O-2表现出稳定的高灵敏度响应，但本研究的重点是根据这些薄膜的灵敏度、响应时间和湿度灵敏度选择最适合用于呼吸监测器的材料。待优化的关键参数包括薄膜的O-2敏感性和薄膜极性，即疏水性程度。这些参数与所使用的前体直接相关。在这项研究中，正丙基三乙氧基硅烷衍生的O-2传感器平台被选为呼吸中O-2分析的最佳材料，因为它的响应时间短，湿度干扰可忽略不计，在相关范围内具有合适的O-2灵敏度，此外还与单点校准策略兼容。
This study focuses on the optimisation and characterisation of novel, ORganically MOdified SILicate (ORMOSIL)-based, hybrid sensor films for use in the detection of O-2 on a breath-by-breath basis in human health monitoring applications. The sensing principle is based on the luminescence quenching of the O-2-sensitive ruthenium complex [Ru(II)-tris(4,7-diphenyl-1,10-phenanthroline)], which has been entrapped in a porous sol-gel film. The detection method employed is that of phase fluorometry using blue LED excitation and photodiode detection. Candidate sensor films include those based on the organosilicon precursors, methyltriethoxysilane, ethyltriethoxysilane, n-propyltriethoxysilane and phenyltriethoxysilane. While it has been established previously by the authors that these films exhibit a stable, highly sensitive response to O-2, this study focuses on selecting the material most suited for use in a breath monitor, based on the sensitivity, response time and humidity sensitivity of these films. Key parameters to be optimised include the O-2 sensitivity of the film and the film polarity, i.e. the degree of hydrophobicity. These parameters are directly linked to the precursors used. In this study a n-propyltriethoxysilane-derived O-2 sensor platform was selected as the optimum material for in-breath O-2 analysis due to its short response time, negligible humidity interference and suitable O-2 sensitivity in the relevant range in addition to its compatibility with a single-point calibration strategy.