IMPACT FACTORS AND THE OPTIMAL PARAMETER OF ACOUSTIC STRUCTURE QUANTIFICATION IN THE ASSESSMENT OF LIVER FIBROSIS
IMPACT FACTORS AND THE OPTIMAL PARAMETER OF ACOUSTIC STRUCTURE QUANTIFICATION IN THE ASSESSMENT OF LIVER FIBROSIS
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声结构量化评估肝纤维化的影响因素及最佳参数
DOI：
10.1016/j.ultrasmedbio.2015.05.006
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Lu, Ming-De
中科院分区：
文献类型：
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作者：
Huang, Yang;Liu, Guang-Jian;Lu, Ming-De
本研究的目的是评估声结构量化（ASQ）超声的影响因素，并找到评估肝纤维化的最佳参数。二十名健康志愿者接受了 ASQ 检查，以评估 ASQ 图像采集和分析的影响因素。另外113名肝病患者接受了标准化ASQ检查，并将结果与肝纤维化的组织学分期进行比较。我们发现右肝脏的 ASQ 参数值低于左肝脏 (p = 0.000-0.021)。除了增益 70 (p = 0.193-1.000) 之外，接收增益没有受到重大影响。对于感兴趣区域中受累血管的不同直径，该组为5.0 mm(p = 0.000-0.062)。然而，感兴趣区域的大小（p = 0.438-1.000）和深度（p = 0.072-0.764）没有统计影响。在图像采集和离线图像分析中都发现了良好的操作员内和操作员间再现性。在肝纤维化研究中，局灶性紊乱比率与组织学纤维化分期的相关性最高（r = 0.67，p < 0.001）。综上所述，检测位置、接收增益和受累血管是ASQ检查的主要影响因素，病灶扰动比是评估肝纤维化的最佳参数。 (C) 2015 年世界超声医学与生物学联合会。
The aims of the present study are to assess the impact factors on acoustic structure quantification (ASQ) ultrasound and find the optimal parameter for the assessment of liver fibrosis. Twenty healthy volunteers underwent ASQ examinations to evaluate impact factors in ASQ image acquisition and analysis. An additional 113 patients with liver diseases underwent standardized ASQ examinations, and the results were compared with histologic staging of liver fibrosis. We found that the right liver displayed lower values of ASQ parameters than the left (p = 0.000-0.021). Receive gain experienced no significant impact except gain 70 (p = 0.193-1.000). With regard to different diameter of involved vessels in regions of interest, the group 5.0 mm(p = 0.000-0.062). However, the region of interest size (p = 0.438-1.000) and depth (p = 0.072-0.764) had no statistical impact. Good intra-and interoperator reproducibilities were found in both image acquisitions and offline image analyses. In the liver fibrosis study, the focal disturbance ratio had the highest correlation with histologic fibrosis stage (r = 0.67, p < 0.001). In conclusion, the testing position, receive gain and involved vessels were the main factors in ASQ examinations and focal disturbance ratio was the optimal parameter in the assessment of liver fibrosis. (C) 2015 World Federation for Ultrasound in Medicine & Biology.