On the development of psychoneuroimmunology
On the development of psychoneuroimmunology
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DOI：
10.1016/s0014-2999(00)00550-1
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发表时间：
2000-09-29
影响因子：
5
通讯作者：
Ader, R
中科院分区：
文献类型：
--
作者：
Ader, R
心理神经免疫学是研究行为、神经、内分泌和免疫过程之间相互作用的学科，在20世纪70年代末形成了一个跨学科的研究领域。这里概述了一些在建立大脑和免疫系统之间的神经解剖学、神经化学和神经内分泌途径以及功能关系方面至关重要的早期研究。这些研究和随后的研究使人们普遍认识到，神经系统和免疫系统是一个完整的适应过程系统的组成部分，免疫调节过程不能再作为自主免疫系统的独立活动来研究。免疫调节过程研究的这种范式转变和对行为诱导的免疫功能改变的潜在机制的阐述，有望更好地理解和重新认识病理生理状态的多个确定的病因。(C)2000 Elsevier Science B.V.保留所有权利。
Psychoneuroimmunology, the study of interactions among behavioral, neural and endocrine, and immune processes, coalesced as an interdisciplinary field of study in the late 1970s. Some of the early research that was critical in establishing neuroanatomical, neurochemical and neuroendocrine pathways and functional relationships between the brain and the immune system is outlined here. These and subsequent studies have led to the general acknowledgment that the nervous and immune systems are components of an integrated system of adaptive processes, and that immunoregulatory processes can no longer be studied as the independent activity of an autonomous immune system. This paradigm shift in the study of immunoregulatory processes and the elaboration of the mechanisms underlying behaviorally induced alterations of immune function promise a better understanding and a new appreciation of the multi-determined etiology of pathophysiological states. (C) 2000 Elsevier Science B.V. All rights reserved.