Meta-analysis of the relationship between HIV infection and risk for depressive disorders
Meta-analysis of the relationship between HIV infection and risk for depressive disorders
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DOI：
10.1176/appi.ajp.158.5.725
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发表时间：
2001-05-01
影响因子：
17.7
通讯作者：
Roberts, JE
中科院分区：
文献类型：
--
作者：
Ciesla, JA;Roberts, JE
目的：调查HIV感染与抑郁症风险之间关系的10项已发表的研究中，每一项都得出结论，HIV阳性个体患抑郁症的风险并不比HIV阴性个体高。本研究使用元分析技术进一步研究抑郁症与HIV感染之间的关系。方法：荟萃分析技术用于汇总和重新分析来自10项研究的数据，这些研究比较了hiv阳性和hiv阴性个体的重度抑郁症（N= 2596）或心境恶劣障碍（N= 1822）的发病率。结果：hiv阳性受试者出现重度抑郁症的频率比hiv阴性对照组高出近2倍。另一方面，关于心境恶劣障碍的研究结果尚无定论。抑郁症的发病率似乎与感染者的性取向或疾病阶段无关。结论：尽管大多数HIV阳性个体似乎具有心理弹性，但这项荟萃分析提供了强有力的证据，证明HIV感染与患重度抑郁症的风险较高有关。未来的研究应该集中在确定这一人群中抑郁症的风险和恢复能力的途径。
Objective: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuals are at no greater risk for depression than comparable HIV-negative individuals. This study used meta-analytic techniques to further examine the relationship between depressive disorders and HIV infection.Method: Meta-analytic techniques were used to aggregate and reanalyze the data from 10 studies that compared HIV-positive and HIV-negative individuals for rates of major depressive disorder (N=2,596) or dysthymic disorder (N=1,822).Results: The frequency of major depressive disorder was nearly two times higher in HIV-positive subjects than in HIV-negative comparison subjects. On the other hand, findings were inconclusive with regard to dysthymic disorder. Rates of depression do not appear to be related to the sexual orientation or disease stage of infected individuals.Conclusions: Although the majority of HIV-positive individuals appear to be psychologically resilient, this meta-analysis provides strong evidence that HIV infection is associated with a greater risk for major depressive disorder. Future research should focus on identifying pathways of risk and resilience for depression within this population.