Biochemical properties of fission yeast homologous recombination enzymes
Biochemical properties of fission yeast homologous recombination enzymes
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裂殖酵母同源重组酶的生化特性
DOI：
10.1016/j.gde.2021.06.006
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Iwasaki Hiroshi
中科院分区：
文献类型：
--
作者：
Tsubouchi Hideo;Argunhan Bilge;Iwasaki Hiroshi
同源重组（HR）是一种从病毒到人类的普遍现象。HR的机制在人类和简单的单细胞真核生物如酵母中基本相同。两个高度分歧的酵母物种，SaccharomycesgraeandSchizoskillomycespombe，已被证明是非常有用的了解真核HR的基本机制，作为一个来源，独特的生物学见解，也相互补充。在这里，我们将回顾S的特性。pombeHR机制与S.以及其他模式生物。特别强调的是将被放在生化表征的HR机制发现使用S。粟蛋白
Homologous recombination (HR) is a universal phenomenon conserved from viruses to humans. The mechanisms of HR are essentially the same in humans and simple unicellular eukaryotes like yeast. Two highly diverged yeast species,Saccharomyces cerevisiaeandSchizosaccharomyces pombe, have proven exceptionally useful in understanding the fundamental mechanisms of eukaryotic HR by serving as a source for unique biological insights and also complementing each other. Here, we will review the features ofS. pombeHR mechanisms in comparison toS. cerevisiaeand other model organisms. Particular emphasis will be put on the biochemical characterization of HR mechanisms uncovered usingS. pombeproteins.