Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, daily maternal separation
Single, intense prenatal stress decreases emotionality and enhances learning performance in the adolescent rat offspring: Interaction with a brief, daily maternal separation
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DOI：
10.1016/j.bbr.2005.12.010
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发表时间：
2006-04-25
影响因子：
2.7
通讯作者：
Cannizzaro, E
中科院分区：
文献类型：
--
作者：
Cannizzaro, C;Plescia, F;Cannizzaro, E
围产期的操作可能会导致后代的神经行为变化。在这项研究中，我们在青春期雄性大鼠中调查了在怀孕16天由120分钟的母体制动引起的单一强烈的产前应激的后果，以及从出生后2天到21天每天短暂的母体隔离的后果：在开阔的场地和高架的正迷宫中无条件的恐惧/焦虑样行为；在“罐子测试”中的学习表现，一种非厌恶的空间和触觉/视觉任务；皮质酮水平在基础和应激诱导条件下的水平。我们的结果表明，产前应激和母体分离程序都会降低情绪性，提高学习成绩。母体分离增强了产前应激诱导的提高学习成绩的效果。基础皮质酮水平和应激诱导的血浆皮质酮水平在产前应激、母体分离和两种程序的组合后都会降低。这些发现表明，单一的、强烈的产前应激可以增强后代的适应性应激相关反应，这可能是由于母体因素的参与。孕期应激和母体分离对学习成绩的协同作用可能是由于子代的下丘脑-垂体-肾上腺轴反应进一步减弱，从而更好地应对所管理的任务。(C)2006爱思唯尔B.V.保留所有权利。
Perinatal manipulations can lead to neurobehavioural changes in the progeny. In this study we investigated, in adolescent male rat offspring, the consequences of a single, intense prenatal stress induced by a 120 min-maternal immobilization at gestational day 16, and of a daily, brief maternal separation from postnatal day 2 until 21, on: unconditioned fear/anxiety-like behaviour in open field and in elevated plus-maze; learning performance in the "Can test", a non-aversive spatial and tactile/visual task; corticosterone plasma levels under basal and stress-induced conditions. Our results indicate that both prenatal stress and maternal separation procedures decrease emotionality and enhance learning performance. Maternal separation potentiates prenatal stress-induced effects in enhancing learning performance. Both basal and stress-induced corticosterone plasma levels are reduced following prenatal stress, maternal separation and the combination of two procedures. These findings suggest that a single, intense prenatal stress can enhance the adaptive stress-related responses in the progeny, probably due to the involvement of maternal factors. The synergistic effect of prenatal stress and maternal separation on learning performance may be due to a further damping of hypothalamic-pituitary-adrenal axis response in the progeny that better cope with the task administered. (C) 2006 Elsevier B.V. All rights reserved.