The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis
The inhibitory principle of lipopolysaccharide-induced nitric oxide production from Inula britannica var. chinensis
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DOI：
10.1007/bf02980051
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发表时间：
2004-01-01
影响因子：
6.7
通讯作者：
Seo, EK
中科院分区：
文献类型：
--
作者：
Je, KH;Han, AR;Seo, EK
倍半萜内酯，1-O-乙酰基-4R,6S-britannilactone (1)，从 Inula britannica L. var. 的花中分离出来。中华草 (Rupr.) Reg. （菊科），首次被发现作为 NOS 抑制成分，IC50 值为 22.1 μM，比阳性对照 L-N-6-(1-亚氨基乙基)赖氨酸 (IC50 = 33.7 μM) 更有效。通过一维和二维核磁共振实验并与参考标准比较，鉴定了化合物 1 的结构。
A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an NOS inhibitory constituent for the first time with an IC50 value of 22.1 muM which is more potent than the positive control, L-N-6-(1-iminoethyl)lysine (IC50 = 33.7 muM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.