Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease
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DOI：
10.1002/cncr.26253
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发表时间：
2012-01-01
期刊：
影响因子：
6.2
通讯作者：
Dabaja, Bouthaina
中科院分区：
文献类型：
--
作者：
Shihadeh, Ferial;Reed, Valerie;Dabaja, Bouthaina
背景：急性髓系白血病（AML）很少累及中枢神经系统（CNS）。这项研究在 AML 患者中进行，以确定细胞遗传学结果是否可以预测中枢神经系统受累。方法：回顾了 2000 年 1 月至 2008 年 12 月期间在德克萨斯大学 MD 安德森癌症中心接受治疗的 1354 名 AML 患者的医疗记录。 40 名患者 (3%) 在就诊或疾病复发时出现 CNS 受累，其中 37 名患者对骨髓抽吸物进行了常规细胞遗传学检查。收集人口统计数据、治疗情况和最后一次随访时的状态。结果：11 名患者（30%）具有二倍体核型，14 名患者（38%）具有复杂的细胞遗传学。 40 名患者中只有 5 名在诊断时患有 CNS 疾病，其余患者在复发时患有 CNS 疾病。发生中枢神经系统疾病的患者年龄较小 (P.019)，诊断时白细胞 (WBC) 计数较高 (P.001)，乳酸脱氢酶 (LDH) 水平较高 (P.001)
BACKGROUND: Acute myeloid leukemia (AML) infrequently involves the central nervous system (CNS). This study was undertaken in patients with AML to determine whether cytogenetic findings predict CNS involvement. METHODS: The medical records of 1354 patients with AML who were treated at The University of Texas MD Anderson Cancer Center between January 2000 and December 2008 were reviewed. Forty patients (3%) had CNS involvement at time of presentation or disease recurrence, of whom 37 had conventional cytogenetics performed on bone marrow aspirate material. Demographics, treatment, and status at last follow- up were collected. RESULTS: Eleven patients (30%) had a diploid karyotype, and 14 patients (38%) had complex cytogenetics. Only 5 of the 40 patients had CNS disease at diagnosis, and the remaining patients had CNS disease at relapse. Patients who developed CNS disease were younger (P.019), had a higher white blood cell (WBC) count at diagnosis (P.001), had higher lactate dehydrogenase level (LDH) levels (P