Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera:: The molluscan counterpart of the annelidan GGNG peptides
Novel excitatory neuropeptides isolated from a prosobranch gastropod, Thais clavigera:: The molluscan counterpart of the annelidan GGNG peptides
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DOI：
10.1016/j.peptides.2005.06.026
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发表时间：
2006-03-01
期刊：
影响因子：
3
通讯作者：
Horiguchi, T
中科院分区：
文献类型：
--
作者：
Morishita, F;Minakata, H;Horiguchi, T
GGNG肽是一种从蚯蚓、水蛭和多毛动物中鉴定出的兴奋性神经肽。从一种软体动物中纯化并鉴定了两个结构相关的肽。泰国兴奋性肽-1 (TEP-1) （KCSGKWAIHACWGGN-NH2）和TEP-2 （KCYGKWAMHACWGGN-NH2）是具有一个二硫键和c端GGN-NH2结构的五肽，大多数GGNG肽具有相同的结构。TEP增强了泰式食管和阴茎复合体的运动性。tep样免疫反应性分布于中枢神经系统的神经元和阴茎复合体的神经末梢。因此，TEP参与了消化和生殖系统的收缩。氨基酸在TEP中的取代表明TEP中的两个色氨酸残基对维持生物活性很重要。(c) 2005爱思唯尔公司版权所有。
The GGNG peptides are excitatory neuropeptides identified from earthworms, leeches and polychaeta. Two structurally related peptides were purified and characterized from a mollusk, Thais clavigera (prosobranch gastropod). The peptides designated as Thais excitatory peptide-1 (TEP-1) (KCSGKWAIHACWGGN-NH2) and TEP-2 (KCYGKWAMHACWGGN-NH2) are pentadecapeptides having one disulfide bond and C-terminal GGN-NH2 Structures, which are shared by most GGNG peptides. TEP augmented the motilities of Thais esophagus and penial complex. TEP-like immunoreactivity is distributed in both the neurons of the central nervous system and nerve endings in the penial complex. Thus, the involvement of TEP in the contraction of the digestive and reproductive systems is suggested. Substitution of amino acids in TEP revealed that two tryptophan residues in TEP are important for maintaining bioactivity. (c) 2005 Elsevier Inc. All rights reserved.