Tolerogenic dendritic cells and myeloid-derived suppressor cells: potential for regulation and therapy of liver auto- and alloimmunity.
Tolerogenic dendritic cells and myeloid-derived suppressor cells: potential for regulation and therapy of liver auto- and alloimmunity.
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DOI：
10.1016/j.imbio.2010.05.024
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发表时间：
2010-09
期刊：
影响因子：
2.8
通讯作者：
Thomson, Angus W.
中科院分区：
文献类型：
--
作者：
Natarajan, Sudha;Thomson, Angus W.
器官移植现已成为终末期肝脏疾病、急性暴发性肝衰竭和肝细胞癌的公认治疗方法。虽然由于免疫抑制药物方案的改进，早期移植物接受率显着增加，但晚期移植物失败率基本保持不变。最近的研究结果表明，除了同种异体免疫，肝移植慢性排斥反应也可能反映了原发性自身免疫性肝炎或先前存在的肝脏自身免疫性疾病的复发。树突状细胞（DC）为基础的治疗是一个有前途的实验方法，以促进移植耐受和治疗自身免疫性疾病。新出现的证据也证明了髓源性抑制细胞（MDSC）在抗原（Ag）特异性调节T细胞应答中的潜在功效。在此，我们讨论了目前对肝移植后自身免疫的理解，沿着目前的方法用于开发致耐受性DC，以及MDSC用于开发稳定的Ag特异性耐受的潜在用途。
Organ transplantation is now established as an accepted treatment for end-stage liver disease, acute fulminant hepatic liver failure and hepatocellular carcinoma. While early graft acceptance rates have increased markedly due to improved immunosuppressive drug regimens, rates of late graft failure remain largely unchanged. Recent findings suggest that, in addition to alloimmunity, chronic rejection of liver allografts may also reflect de novo autoimmune hepatitis or recurrence of pre-existing hepatic autoimmune disease. Dendritic cell (DC)-based therapy is a promising experimental approach to promotion of transplant tolerance and the treatment of autoimmune diseases. Newly-emerging evidence also demonstrates the potential efficacy of myeloid-derived suppressor cells (MDSC) in the antigen (Ag)-specific regulation of T cell responses. Herein, we discuss current understanding of liver autoimmunity post transplantation, along with current approaches for the development of tolerogenic DC, and the potential use of MDSC for the development of stable, Ag-specific tolerance.
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影响因子：
32.4
作者：
Goubier, Anne;Dubois, Bertrand;Gheit, Hanane;Joubert, Grgoire;Villard-Truc, Florence;Asselin-Paturel, Carine;Trinchieri, Giorgio;Kaiserlian, Dominique
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