Insulin resistance, inflammation, and serum fatty acid composition
Insulin resistance, inflammation, and serum fatty acid composition
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DOI：
10.2337/diacare.26.5.1362
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发表时间：
2003-05-01
期刊：
影响因子：
16.2
通讯作者：
Ricart, W
中科院分区：
文献类型：
--
作者：
Fernández-Real, JM;Broch, M;Ricart, W
目的——脂肪酸（FA）与胰岛素抵抗和肥胖等慢性炎症性疾病的发生有关。然而，胰岛素抵抗、肥胖、炎症活动（循环白介素 [IL]-6）和饮食 FA 之间的关系在其他健康受试者中几乎没有研究过。 研究设计和方法 - 我们旨在研究 I 3. 2.4 kg/m(2) [平均值 +/- SD]）受试者和 109 名瘦人（BMI 21.7 +/- 1.7 超重（BMI 26.9 +/- 2.4）中的这些相互作用。 kg/m(2), P < 0.000001) 受试者通过免疫测定法测量 IL-6，通过气相色谱法测量 FA。结果 饱和 FAs 的百分比 (r = 0.30, P = 0.01) 和 omega-6 FAs (r = -0.32, P = 0.001) 与循环 IL-6 显着相关，而 omega-3 FAs 的百分比则呈负相关。在超重受试者中，饱和 omega-3 和饱和 omega-6 FA 比率分别与 C 反应蛋白 (P < 0.0001) 和 IL-6 (P < 0.001) 呈显着正相关，而在瘦受试者中，这些关联均未达到统计学显着性（稳态模型评估值）。油酸 (C20:0)（p = 亚油酸 (C 8:2 omega6) (P = 0.03 .04)、山萮酸 (C22:0 (P = 0.009)、二十四烷酸 (C24:0) (P = 0.02) 和神经酸 (C24:1) 的百分比显着较高 (P = 0.03) 且水平显着较低omega9) (P - 0.001) FAs 高于其余受试者，同时，大多数胰岛素敏感受试者的 C 反应蛋白显着降低 (P = 0.03)，与不吸烟男性的亚油酸和二十碳五烯酸百分比显着相关（分别为 P = 0.03 和 P = 0.04），与不吸烟女性的二十二碳六烯酸显着相关（r = 0.04）。 -0.46，P < 0.0001）我们构建了一个多变量回归分析来预测循环 IL-6：年龄、BMI、腰臀比 (WHR)、吸烟状况以及饱和脂肪酸与 omega-6 或饱和脂肪酸与 omega-3 的关系分别被视为男性和女性的自变量，在超重男性中，饱和脂肪酸与 omega-3 脂肪酸的比率 (P = 0.01)，但不是年龄。性别、BM、I、WHIZ 或吸烟状况独立地影响了 17% 的 IL-6 变异。在瘦男性中，吸烟状况 (P = 0.02)，而非其他变量，导致了 8% 的 IL-6 变异。 结论 - 膳食 FA（根据血浆 FA 浓度推断）似乎与超重受试者和胰岛素抵抗受试者的炎症活动有关。标记。
OBJECTIVE - Fatty acids (FAs) have been involved in the development of chronic inflammatory conditions such as insulin resistance and obesity. However, the relation among insulin resistance, obesity, inflammatory activity (circulating interleukin [IL]-6) and dietary FAs has been scarcely studied in otherwise healthy subjects.RESEARCH DESIGN AND METHODS - We aimed to study these interactions in I 3. 2.4 kg/m(2) [means +/- SD]) subjects and 109 lean (BMI 21.7 +/- 1.7 overweight (BMI 26.9 +/- 2.4 kg/m(2), P < 0.000001) subjects. IL-6 was measured by immunoassay and FA by gas liquid cromatography.RESULTS The percentage of saturated FAs (r = 0.30, P = 0.01) and omega-6 FAs (r = -0.32, P = 0.001) were significantly associated with circulating IL-6; whereas the percentage of omega-3 FAs correlated negatively with C-reactive protein in overweight subjects (P = 0.04). Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively. In contrast, none of these associations reached statistical significance in lean subjects. Those subjects in the most insulin-sensitive quintile (homeostasis model assessment value) showed a significantly higher percentage of (P = 0.03) and a significantly lower level of araquidic (C20:0) (p = linoleic acid (C 8:2 omega6) (P = 0.03 .04), behenic (C22:0 (P = 0.009), lignoceric (C24:0) (P = 0.02), and nervonic (C24:1 omega9) (P - 0.001) FAs than the remaining subjects. In parallel, the most insulin-sensitive subjects showed significantly decreased C-reactive protein (P = 0.03). Serum C-reactive protein was significantly associated with percent linoleic acid and eicosapentaenoic acid in nonsmoking men (P = 0.03 and P = 0.04, respectively) and with docosahexaenoic acid in nonsmoking women (r = -0.46, P < 0.0001). We constructed a multivariant regression analysis to predict circulating IL-6: Age, BMI, waist-to-hip ratio (WHR), smoking status, and the relation of saturated to omega-6 or saturated to omega-3 FAs were considered as independent variables separately in men and women. In over-weight men, the ratio of saturated to omega-3 FAs (P = 0.01), but not age, sex, BM,I, WHIZ, or smoking status, independently contributed to 17% of IL-6 variance. In lean men, smoking status (P = 0.02), but not the remaining variables, contributed to 8% of IL-6 variance.CONCLUSIONS - Dietary FAs (as inferred from plasma FA concentration) seem to be linked to inflammatory activity in overweight subjects and in subjects with insulin resistance. Being overweight modulates the relation of FAs to inflammatory markers.