Mapping of HPV-11 E1 binding site and determination of other important cis elements for replication of the origin.
Mapping of HPV-11 E1 binding site and determination of other important cis elements for replication of the origin.
复制标题
绘制 HPV-11 E1 结合位点图谱并确定复制起点的其他重要顺式元件。
DOI：
10.1006/viro.1996.0050
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
McCance,DJ
中科院分区：
文献类型：
--
作者：
Sun,YN;Lu,JZ;McCance,DJ
The viral proteins E1 and E2 are essential for the replication of the HPV-11 origin. We have now mapped the E1 binding site (E1BS) and show by mutation analysis that the E1BS and an adjoining poly(A)-rich region are necessary for efficient replication of the origin. We have also shown, using suboptimal levels of E1 protein, that enhancement of E1 binding by E2 partially protects the E1BS. Finally, we show that E1 can enhance the binding of E2 even in the absence of the E1BS.
