Fibrinolysis and host response in bacterial infections
Fibrinolysis and host response in bacterial infections
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DOI：
10.1160/th07-02-0117
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发表时间：
2007-09-01
影响因子：
6.7
通讯作者：
Hammerschmidt, Sven
中科院分区：
文献类型：
--
作者：
Bergmann, Simone;Hammerschmidt, Sven
纤溶酶原激活系统是纤维蛋白溶解的一部分，它受到各种激活剂和抑制剂的严格调节和保护，以防止功能障碍。然而，包括细菌、真菌和寄生虫在内的微生物已被证明以一种特定的方式与纤维蛋白溶解途径的成分相互作用。致病菌能够破坏蛋白酶、激活剂或抑制剂的功能，包括在宿主内传播和逃避宿主的炎症免疫反应。在这里，我们提供了细菌与纤维蛋白溶解系统的成分相互作用并利用该系统进行入侵的各种策略的最新概况。此外，还将介绍纤维蛋白溶解级联因子在不同细菌感染引起的炎症宿主反应中的作用。
The plasminogen activation system is part of the fibrinolysis which is tightly regulated and protected against dysfunction by various activators and inhibitors. However, microorganisms including bacteria, fungi and also parasites have been proven to interact in a specific manner with components of the fibrinolytic pathways. Pathogenic bacteria are capable to subvert the function of proteases, activators or inhibitors for their own benefits including dissemination within the host and evasion of host inflammatory immune response. Here, we provide a state of the art overview of the divers strategies employed by bacteria to interact with components of the fibrinolytic system and to exploit the system for invasion. Moreover, the role of factors of the fibrinolytic cascade in inflammatory host response due to different bacterial infections will be presented.