Self-assembly of anionic porphyrins and alkaline or alkaline earth metal ions mediated by cucurbit[7,8]uril.
Self-assembly of anionic porphyrins and alkaline or alkaline earth metal ions mediated by cucurbit[7,8]uril.
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DOI：
10.1002/cphc.201201025
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发表时间：
2013-04
期刊：
影响因子：
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通讯作者：
Wanhua Lei;Guoyu Jiang;Qianxiong Zhou;Yuan-jun Hou;Bao-wen Zhang;Xuexin Cheng;Xuesong Wang
中科院分区：
文献类型：
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作者：
Wanhua Lei;Guoyu Jiang;Qianxiong Zhou;Yuan-jun Hou;Bao-wen Zhang;Xuexin Cheng;Xuesong Wang
基于生物普遍离子的纳米级配位聚合物在药物输送和生物医学成像方面具有潜在的应用。在此，在葫芦[7]脲（CB7）存在下，在水溶液中构建了阴离子卟啉（包括内消旋四（4-羧基苯基）-卟啉（H2 TCPP（4-））和内消旋四（4-磺基苯基）-卟啉（H2 TPPS（4-））以及碱金属或碱土金属阳离子（例如K（+）和Ca（2+））的配位聚合物纳米颗粒。或葫芦[8]uril (CB8)。应用紫外/可见吸收光谱和荧光光谱、动态光散射（DLS）、扫描电子光谱（SEM）和原子力显微镜（AFM）来探索CBn介导的卟啉阴离子和金属阳离子的组装和颗粒形成。颗粒尺寸取决于CBn和金属阳离子的种类及其浓度。在37℃下，肿瘤细胞（A549细胞）对H2 TPPS（4-）颗粒的摄取效率比H2 TPPS（4-）更有效，显示了这种组装颗粒在生物学和医学中的应用潜力。
Nanoscaled coordination polymers based on biologically prevalent ions have potential applications in drug delivery and biomedical imaging. Herein, coordination polymer nanoparticles of anionic porphyrins, including meso-tetra(4-carboxyphenyl)-porphyrin (H2 TCPP(4-)) and meso-tetra(4-sulfonatophenyl)-porphyrin (H2 TPPS(4-)), and alkaline or alkaline earth metal cations, such as K(+) and Ca(2+), were constructed in aqueous solution in the presence of cucurbit[7]uril (CB7) or cucurbit[8]uril (CB8). UV/Vis absorption and fluorescence spectroscopy, dynamic light scattering (DLS), scanning electron spectroscopy (SEM), and atomic force microscopy (AFM) were applied to explore the assembly and particle formation of porphyrin anions and metal cations mediated by CBn. The particle size depends on the kinds of CBn and metal cations and their concentrations. The uptake of H2 TPPS(4-) particles by tumor cells (A549 cells) was found to be more efficient than H2 TPPS(4-) at 37 °C, showing the application potential of such assembled particles in biology and medicine.