Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR–α Activators
Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR–α Activators
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PPAR-α 激活剂对心血管疾病肝脏炎症风险标志物的调节
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
BartStaels
中科院分区：
文献类型：
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作者：
AlbertoZambon;PhilippeGervois;PaoloPauletto;Jean;BartStaels
动脉粥样硬化是一种长期慢性炎症性疾病，与炎症性肝脏标志物（如CRP和纤维蛋白原）浓度升高以及外周来源（如肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6）相关。过氧化物酶体增殖物激活受体（Peroxisome proliferator-activated receptor，PPAR-）-α是一种配体激活的转录因子，可调节脂质稳态中关键基因的表达，并调节血管壁和肝脏的炎症反应。PPAR-α被天然配体激活，如脂肪酸，以及降脂贝特类。PPAR-α激动剂对动脉粥样硬化形成的不同阶段的影响：（1）动脉粥样硬化的早期标志物如血管壁反应性得到改善，（2）内皮细胞表面粘附分子表达减少，伴随炎性细胞因子如TNF-α、IL-1和IL-6水平降低，导致白细胞向动脉壁募集减少;（3）在后期阶段，...
Atherosclerosis is a long-term chronic inflammatory disease associated with increased concentrations of inflammatory hepatic markers, such as CRP and fibrinogen, and of peripheral origin, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6. Peroxisome proliferator-activated receptor (PPAR-)-α is a ligand-activated transcription factor that regulates expression of key genes involved in lipid homeostasis and modulates the inflammatory response both in the vascular wall and the liver. PPAR-α is activated by natural ligands, such as fatty acids, as well as the lipid-lowering fibrates. PPAR-α agonists impact on different steps of atherogenesis: (1) early markers of atherosclerosis, such as vascular wall reactivity, are improved, (2) however, reduced expression of adhesion molecules on the surface of endothelial cells, accompanied by decreased levels of inflammatory cytokines, such as TNF-α, IL-1, and IL-6, leads to a decreased leukocyte recruitment into the arterial wall; (3) in later stages of the at...