Highly selective dummy molecularly imprinted polymer as a solid-phase extraction sorbent for five bisphenols in tap and river water.
Highly selective dummy molecularly imprinted polymer as a solid-phase extraction sorbent for five bisphenols in tap and river water.
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DOI：
10.1016/j.chroma.2014.03.063
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
Xiaoli Sun;Jincheng Wang;Yun Li;Jing Jin;Baoqin Zhang;Syed Mazhar Shah;Xueli Wang;Jiping Chen
中科院分区：
文献类型：
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作者：
Xiaoli Sun;Jincheng Wang;Yun Li;Jing Jin;Baoqin Zhang;Syed Mazhar Shah;Xueli Wang;Jiping Chen
这里提出了一种用于虚拟模板选择和聚合物成分优化的简单快速的方法。通过在非印迹聚合物（NIP）柱上运行并以致孔剂溶剂作为流动相来筛选一系列用于双酚印迹的虚拟模板。测试的虚拟模板主要涉及双酚S（BPS）、溴双酚A（TBBPA）、双酚F（BPF）、双酚E（BPE）、双酚B（BPB）、双酚AF（BPAF）、2,2',6,6'-四甲基-4,4'-磺酰基联苯酚（BS-TM）和4,4'-二氨基二苯甲烷（DADPM）。还使用相同的方法研究了不同单体和致孔剂的 BPS 和 DADPM。最终选择BPS虚拟模板，以乙腈和4-VP作为致孔剂和单体。所得的虚拟分子印迹聚合物 (DMIP) 对 BPF、BPE、BPA、BPB 和 BPAF 具有优异的亲和力，印迹因子分别为 14.5、13.8、8.7、5.7 和 4.2。开发了一种基于 BPS-DMIP-SPE 与 HPLC-UV 结合的有效方法，用于选择性萃取水样中的 BPF、BPE、BPA、BPB 和 BPAF。该方法对自来水和河水样品在三个浓度水平（40、200 和 1000 ng L−1）下的加标表现出优异的回收率 (89.4–102.0%) 和精密度 (RSD 0.3–4.8%,n= 5)。样品体积为 500 mL 时，检测限范围为 2.2 至 3.8 ng L−1。结果证明了优化方法在 ng L−1 水平选择性提取水样中 BP 的优越性。
A simple and fast method for both dummy template selection and polymer composition optimization is proposed here. A series of dummy templates for bisphenols imprinting were screened by running them on a non-imprinted polymer (NIP) column with porogen solvent as mobile phase. The tested dummy templates mainly involved bisphenol S (BPS), bromobisphenol A (TBBPA), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), 2,2′,6,6′-tetramethyl-4,4′-sulfonyldiphenol (BS-TM) and 4,4′-diaminodiphenylmethane (DADPM). Different monomers and porogens were also investigated for BPS and DADPM using the same method. BPS dummy template was finally selected with acetonitrile and 4-VP as porogen and monomer. The resulting dummy molecularly imprinted polymer (DMIP) achieved superior affinities for BPF, BPE, BPA, BPB and BPAF with imprinting factors 14.5, 13.8, 8.7, 5.7 and 4.2, respectively. An efficient method based on BPS-DMIP-SPE coupled with HPLC-UV was developed for selective extraction of BPF, BPE, BPA, BPB and BPAF in water samples. The method showed excellent recoveries (89.4–102.0%) and precision (RSD 0.3–4.8%,n= 5) for tap and river water samples spiked at three concentration levels each (40, 200 and 1000 ng L−1). The detection limits ranged between 2.2 and 3.8 ng L−1with a sample volume of 500 mL. The result demonstrated the superiority of the optimized method for selective extraction of BPs in water samples at the ng L−1level.