Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum.
Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum.
复制标题
环状 AMP 在细胞粘菌盘基网柄菌中诱导茎细胞分化。
DOI：
10.1073/pnas.65.1.110
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发表时间：
1970
影响因子：
11.1
通讯作者：
J. Bonner
中科院分区：
文献类型：
--
作者：
J. Bonner
环状AMP是盘基网柄菌的细胞引诱剂(Acrasin)，它会使分离的、未聚集的细胞直接转化为含有厚纤维素壁和大液泡的柄细胞。从以前的工作中我们知道，在细胞团中，acrasin只在果期的茎形成区域产生，茎的形成涉及高水平的分解代谢，环状AMP在其他系统中刺激分解代谢酶。这些事实表明，在盘状芽孢杆菌的发育过程中，环状AMP可能是茎细胞分化的关键因素。
Cyclic AMP, which is a cell attractant (acrasin) for Dictyostelium discoideum, will cause isolated, unaggregated cells to turn directly into stalk cells containing thick celluloselike walls and large vacuoles. From previous work we know that in the cell mass, acrasin is produced solely in the region of stalk formation during fruiting, that stalk formation involves a high level of catabolism, and that cyclic AMP stimulates catabolic enzymes in other systems. These facts obviously suggest that in the development of D. discoideum, cyclic AMP might be a key factor in stalk cell differentiation.