Novel roles for Sm-class RNAs in the regulation of gene expression.
Novel roles for Sm-class RNAs in the regulation of gene expression.
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Sm 类 RNA 在基因表达调控中的新作用。
DOI：
10.1080/15476286.2018.1467176
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发表时间：
2018
期刊：
影响因子：
4.1
通讯作者：
Cazalla,Demián
中科院分区：
文献类型：
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作者：
Cazalla,Demián
病毒在感染过程中巧妙地调节宿主基因的表达。许多这样做，部分是通过表达非编码RNA。最近的研究表明，HSUR 2，一种由致癌性疱疹病毒saimiri表达的病毒非编码RNA，通过一种新的机制调节mRNA的表达。感染细胞中HSUR 2与靶mRNA和宿主miRNA的碱基对。这导致宿主miRNA和相关Ago蛋白向靶mRNA的HSUR 2依赖性募集，以及随后的靶mRNA的不稳定。利用这种机制，这种病毒在病毒感染期间调节关键的细胞通路。在这里，我讨论了我们对HSUR功能的思考的演变，并探讨了最近发现的影响，这些发现与目前对miRNA和其他类别的非编码RNA之间相互作用的功能的看法有关，这种基因表达调控机制的潜在优势，以及HSUR 2的进化起源。
Viruses masterfully regulate host gene expression during infection. Many do so, in part, by expressing non-coding RNAs. Recent work has shown that HSUR 2, a viral non-coding RNA expressed by the oncogenicHerpesvirus saimiri, regulates mRNA expression through a novel mechanism. HSUR 2 base pairs with both target mRNAs and host miRNAs in infected cells. This results in HSUR 2-dependent recruitment of host miRNAs and associated Ago proteins to target mRNAs, and the subsequent destabilization of target mRNAs. Using this mechanism, this virus regulates key cellular pathways during viral infection. Here I discuss the evolution of our thinking about HSUR function and explore the implications of recent findings in relation to the current views on the functions of interactions between miRNAs and other classes of non-coding RNAs, the potential advantages of this mechanism of regulation of gene expression, and the evolutionary origin of HSUR 2.