Few changes observed in polysomnographic-assessed sleep before and after completion of chemotherapy.
Few changes observed in polysomnographic-assessed sleep before and after completion of chemotherapy.
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化疗完成前后多导睡眠图评估的睡眠几乎没有观察到变化。
DOI：
10.1016/j.jpsychores.2011.08.003
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发表时间：
2011
影响因子：
4.7
通讯作者：
Huston,Alissa
中科院分区：
文献类型：
--
作者：
Roscoe,JosephA;Perlis,MichaelL;Pigeon,WilfredR;O'Neill,KristenH;Heckler,CharlesE;Matteson-Rusby,SaraE;Palesh,OxanaG;Shayne,Michelle;Huston,Alissa
目的：睡眠障碍在化疗患者中普遍存在，并且与癌症相关性疲劳（CRF）密切相关。然而，关于化疗前后睡眠模式的客观证据很少。方法招募26例计划接受化疗的患者。在第一次化疗前、最后一次化疗后约3周和最后一次治疗后3个月，通过实验室多导睡眠图（PSG）连续两晚评估睡眠参数。在两晚PSG评估的每个晚上的第一个晚上测量疲劳。我们关注慢波睡眠（SWS），因为我们假设这种恢复性睡眠阶段的减少可能与CRF有关。结果：在四个睡眠结构阶段（第一阶段、第二阶段、SWS和REM睡眠）中，从基线到后期时间点的睡眠时间比例变化的重复测量分析无显著性，均为0.41。典型相关分析显示，在三个评估点上，花在SWS上的时间比例与三个CRF测量值中的任何一个都没有显著相关，P=0.28。结论肿瘤治疗不影响睡眠结构。没有证据表明CRF和SWS之间存在关联，也没有发现SWS的改变。
OBJECTIVESleep disturbance is prevalent among patients undergoing chemotherapy and is strongly associated with cancer-related fatigue (CRF). However, little objective evidence has been gathered on the patterns of sleep before and following chemotherapy.METHODSTwenty-six patients scheduled to receive chemotherapy were recruited. Sleep parameters were assessed by in-lab polysomnography (PSG) for two consecutive nights prior to first chemotherapy, approximately 3weeks following the patients' last chemotherapy, and 3months following the last treatment. Fatigue was measured on the first night of each of the two-night PSG assessments. We focus on Slow-Wave Sleep (SWS) as we hypothesized that a decrease of this restorative phase of sleep might be implicated in CRF.RESULTSRepeated-measures analyses examining changes from baseline to the later time points in the proportion of time asleep spent in each of the four sleep architecture stages (Stage 1, Stage 2, SWS, and REM sleep) were non-significant, all Ps>0.41. Canonical correlation analysis showed that the proportion of time spent in SWS was not significantly correlated with any of the three CRF measures at any of the three assessment points, P=0.28.CONCLUSIONSSleep architecture is not affected by cancer treatment. No evidence of an association between CRF and SWS, or alterations in SWS, was found.