Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles.
Co-administration of Microbubbles and Drugs in Ultrasound-Assisted Drug Delivery: Comparison with Drug-Carrying Particles.
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DOI：
10.1007/978-3-319-22536-4_12
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发表时间：
2016
影响因子：
--
通讯作者：
R. Suzuki;A. Klibanov
中科院分区：
文献类型：
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作者：
R. Suzuki;A. Klibanov
有两种可供选择的超声波辅助药物输送方法。首先，药物可以被包裹在超声响应颗粒中或附着在超声响应颗粒上，并在血管系统中给药，以实现超声触发的药物从颗粒中释放并响应于靶区的超声治疗而局部组织沉积。其次，该药物可以与微泡或其他声敏颗粒一起给药。在这种情况下，超声波对颗粒(充当空化核)的作用导致生理屏障通透性的瞬时改善，从而使循环中的药物能够离开血流，进入靶组织和细胞。我们讨论和比较这两种方法，它们在特定的药物输送场景中的特点和优缺点。显然，基于现有批准的微泡和药物(或药物载体)的标签外使用的系统将有机会更快地进入临床试验，并花费更少的资源。然而，如果声敏药物载体的优越治疗潜力被证明，并且配方稳定性问题得到适当的解决，这种方法可能会找到它的实际用途，特别是在核酸递送的情况下。
There are two alternative approaches to ultrasound-assisted drug delivery. First, the drug can be entrapped into or attached onto the ultrasound-responsive particles and administered in the vasculature, to achieve ultrasound-triggered drug release from the particles and localized tissue deposition in response to ultrasound treatment of the target zone. Second, the drug can be co-administered with the microbubbles or other sonosensitive particles. In this case, the action of ultrasound on the particles (which act as cavitation nuclei) results in the transient improvement of permeability of the physiological barriers, so that the circulating drug can exit the bloodstream and get into the target tissues and cells. We discuss and compare both of these approaches, their characteristic advantages and disadvantages for the specific drug delivery scenarios. Clearly, the system based on the off-label use of the existing approved microbubbles and drugs (or drug carriers) will have a chance of getting to clinical trials faster and with lesser resources spent. However, if a superior curative potential of a sonosensitive drug carrier is proven, and formulation stability problems are addressed properly, this approach may find its way to practical use, especially for nucleic acid delivery scenarios.