Is Helicobacter pylori infection inversely correlated with atopic, skin, and autoimmune diseases?
Is Helicobacter pylori infection inversely correlated with atopic, skin, and autoimmune diseases?
复制标题
DOI：
10.1111/all.15306
复制
发表时间：
2022-09
期刊：
影响因子：
12.4
通讯作者：
T. Yasuma;C. D'Alessandro-Gabazza;H. Fujimoto;Tetsu Kobayashi;I. Imoto;E. Gabazza
中科院分区：
文献类型：
--
作者：
T. Yasuma;C. D'Alessandro-Gabazza;H. Fujimoto;Tetsu Kobayashi;I. Imoto;E. Gabazza
阅读Cho等人关于螺杆菌（H .幽门螺杆菌感染和胃外表现发表在过敏。1幽门螺杆菌感染是胃炎、消化性溃疡、胃腺癌和粘膜相关淋巴组织淋巴瘤的一个公认的致病因素，但幽门螺杆菌感染与胃粘膜相关淋巴组织淋巴瘤的关系尚不清楚。幽门螺杆菌感染的胃外表现仍有争议。作者在韩国进行了一项全国性的人群研究，证明了H。幽门螺杆菌感染与特应性疾病、皮肤病和自身免疫性疾病呈负相关。1与特应性疾病（过敏性鼻炎、哮喘和特应性皮炎）和某些自身免疫性疾病（溃疡性结肠炎、克罗恩病）的负相关性与先前显示H.幽门感染2，3然而，我们在解释某些皮肤病（接触性皮炎、红斑痤疮和荨麻疹）与自身免疫性疾病（类风湿性关节炎、干燥综合征和系统性红斑狼疮）之间观察到的负相关性的生理病理学意义时应谨慎。虽然这种反比关系暗示了H. pylori感染，作者使用基于药物处方的方法将患者分类为H. pylori阳性或H. pylori阴性。这种状态的可能性很高，
read the study by Cho et al. on the association between Helicobacter ( H . ) pylori infection and extragastric manifestations published in Allergy. 1 Helicobacter pylori infection is a well- recognized causative factor of gastritis, peptic ulcer disease, gastric adenocarcinoma, and mucosa- associated lymphoid tissue lymphoma, but the link of H. pylori infection with extragastric manifestations remains controversial. 2 The authors undertook a nationwide population- based study in Korea and demonstrated that H. pylori infection is inversely correlated with atopic, skin, and autoimmune diseases. 1 The inverse correlation with atopic disorders (allergic rhinitis, asthma, and atopic dermatitis) and some autoimmune diseases (ulcerative colitis, Crohn's disease) is consistent with previous reports showing protective activity of H. pylori infection. 2,3 However, we should be cautious in explaining the physiopathological implication of the inverse correlation observed between some skin diseases (contact dermatitis, rosacea, and urticaria) and autoimmune disorders (rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus). Although the inverse relationship implies a protective role of H. pylori infection, the drug prescription- based ap-proach used by the authors to categorize the patients into H. pylori positive or H. pylori - negative the of the results. the high possibility of the status the