Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles
Using itraconazole to clear Batrachochytrium dendrobatidis infection, and subsequent depigmentation of Alytes muletensis tadpoles
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DOI：
10.3354/dao02008
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发表时间：
2009-02-25
影响因子：
1.4
通讯作者：
Fisher, M. C.
中科院分区：
文献类型：
--
作者：
Garner, T. W. J.;Garcia, G.;Fisher, M. C.
树突巴氏杆菌(Batrachochytrium Dendrobatidis，Bd)是两栖动物生物多样性的全球性威胁。目前通过圈养繁殖进行保护的呼声要求针对目标物种开发有效和可靠的抗真菌治疗方法。在此，我们证实抗真菌药物伊曲康唑是一种有效的治疗线虫幼虫感染的药物。极低的剂量，只需7次，就能在治疗后长达28天的时间内有效地清除蝌蚪的感染。然而，我们不能推荐伊曲康唑作为治疗这种物种的方法，因为观察到了蝌蚪的脱色。需要进一步的研究来确定这种治疗的假定肝毒性。
Batrachochytrium dendrobatidis (Bd) is a global threat to amphibian biodiversity. Current calls for conservation through captive breeding require that efficient and reliable antifungal treatments be developed for target species. Here we confirm that the antifungal itraconazole is an effective treatment for infection in larval Alytes muletensis. Exceptionally low doses applied as few as 7 times were effective at clearing infection from tadpoles for up to 28 d after treatment. However, we cannot recommend itraconazole as a treatment for this species as depigmentation of tadpoles was observed. Further research is required to determine the putative hepatotoxicity of this treatment.