Piwi Proteins and piRNAs step onto the systems biology stage.
Piwi Proteins and piRNAs step onto the systems biology stage.
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DOI：
10.1007/978-1-4939-1221-6_5
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发表时间：
2014
影响因子：
--
通讯作者：
Lau, Nelson C.
中科院分区：
文献类型：
--
作者：
Clark, Josef P.;Lau, Nelson C.
Animal germ cells are totipotent because they maintain a highly unique and specialized epigenetic state for its genome. To accomplish this, germ cells express a rich repertoire of specialized RNA binding protein complexes such as the Piwi proteins and Piwi-interacting RNAs (piRNAs): a germ-cell enriched pathway of the RNA interference (RNAi) phenomenon which includes microRNA and endogenous small interfering RNA pathways. Piwi proteins and piRNAs are deeply conserved in animal evolution and play essential roles in fertility and regeneration. Molecular mechanisms for how these specific ribonucleoproteins act upon the transcriptome and genome are only now coming to light with the application of new systems-wide approaches in both invertebrates and vertebrates. Systems biology studies on invertebrates have revealed that transcriptional and heritable silencing is a main mechanism driven by Piwi proteins and piRNA complexes. In vertebrates, Piwi targeting mechanisms and piRNA biogenesis have progressed, while the discovery that the nuclease activity of Piwi protein is essential for vertebrate germ cell development but not completely required in invertebrates highlights the many complexities of this pathway in different animals. This review recounts how recent systems-wide approaches have a rapidly accelerated our new appreciation for the broad reach of the Piwi pathway on germline genome regulation and what questions facing the field await to be unraveled.
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影响因子：
64.5
作者：
Ashe A;Sapetschnig A;Weick EM;Mitchell J;Bagijn MP;Cording AC;Doebley AL;Goldstein LD;Lehrbach NJ;Le Pen J;Pintacuda G;Sakaguchi A;Sarkies P;Ahmed S;Miska EA
通讯作者：
Miska EA
DOI：
10.1073/pnas.0911640106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Chen, Chen;Jin, Jing;Pawson, Tony
通讯作者：
Pawson, Tony
影响因子：
4
作者：
Ambros, Victor
通讯作者：
Ambros, Victor
DOI：
10.1126/science.1190809
发表时间：
2010-06-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cifuentes D;Xue H;Taylor DW;Patnode H;Mishima Y;Cheloufi S;Ma E;Mane S;Hannon GJ;Lawson ND;Wolfe SA;Giraldez AJ
通讯作者：
Giraldez AJ
影响因子：
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