Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.
Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.
复制标题
正常、IIa 型、III 型和 IV 型高脂蛋白血症个体餐后脂蛋白代谢的不同模式。
DOI：
10.1172/jci112926
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Breslow,JL
中科院分区：
文献类型：
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作者：
Weintraub,MS;Eisenberg,S;Breslow,JL
为了研究外源性脂肪代谢，我们使用了维生素 A 脂肪负荷试验，该试验用棕榈酸视黄酯 (RP) 专门标记肠源性脂蛋白。餐后 RP 浓度在总血浆、乳糜微粒（Sf 大于 1,000）和非乳糜微粒（Sf 小于 1,000）部分中进行跟踪。在正常受试者中，餐后脂蛋白存在时间超过14小时，乳糜微粒水平与脂蛋白脂肪酶活性呈负相关，空腹高密度脂蛋白（HDL）胆固醇水平和非乳糜微粒水平与肝甘油三酯脂肪酶活性呈负相关。 IV 型患者的主要异常是乳糜微粒分数增加了 5.6 倍，而 III 型患者的主要异常是非乳糜微粒分数增加了 6.4 倍。 IIa 型患者的乳糜微粒分数异常低。在 IV 型患者中，吉非贝齐减少，而在 IIa 型患者中，消胆胺使乳糜微粒分数分别增加 66% 和 88%。这项研究表明，正常人和患者的餐后血脂异常严重且持续时间长。这些颗粒可能会导致动脉粥样硬化，它们在人类动脉粥样硬化中的作用值得进一步研究。
To study exogenous fat metabolism, we used the vitamin A-fat loading test, which specifically labels intestinally derived lipoproteins with retinyl palmitate (RP). Postprandial RP concentrations were followed in total plasma, and chylomicron (Sf greater than 1,000) and nonchylomicron (Sf less than 1,000) fractions. In normal subjects postprandial lipoproteins were present for more than 14 h, and chylomicron levels correlated inversely with lipoprotein lipase activity and fasting high density lipoprotein (HDL) cholesterol levels and nonchylomicron levels correlated inversely with hepatic triglyceride lipase activity. The main abnormality in type IV patients was a 5.6-fold increase in the chylomicron fraction, whereas in type III patients it was a 6.4-fold increase in nonchylomicrons. Type IIa patients had abnormally low chylomicron fractions. In type IV patients gemfibrozil decreased, whereas in type IIa patients cholestyramine increased the chylomicron fraction 66 and 88%, respectively. This study demonstrates an unexpectedly large magnitude and long duration of postprandial lipemia in normal subjects and patients. These particles are potentially atherogenic, and their role in human atherosclerosis warrants further study.