Relationship between Blood Levels of Heavy Metals and Parkinson's Disease in China
Relationship between Blood Levels of Heavy Metals and Parkinson's Disease in China
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DOI：
10.1159/000255462
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发表时间：
2010-01-01
影响因子：
5.7
通讯作者：
Kanda, Hideyuki
中科院分区：
文献类型：
--
作者：
Fukushima, Tetsuhito;Tan, Xiaodong;Kanda, Hideyuki
背景：已知特发性帕金森病（PD）和由锰（Mn）中毒引起的帕金森综合征在症状上难以区分。因此，我们怀疑许多在日常生活中体内积累了锰的患者被诊断为特发性PD。我们研究了帕金森病与血液重金属水平之间的关系，以及一般人群食物摄入的影响。方法：研究对象包括 2006 年至 2008 年间从中国湖北省襄樊市第一人民医院门诊招募的 PD 患者以及性别和年龄匹配的对照。获得 PD 诊断前的饮食习惯和其他因素的信息。早餐前采集早晨血样，用于测量金属浓度。结果：PD患者的全血Mn和血清铁（Fe）水平显着高于对照组。然而，各组之间从食物中摄入的每种金属或锰中毒经历没有差异。结论：在中国，未知途径的锰和铁积累可能与普通人群帕金森病的病因有关。版权所有 (C) 2009 S. Karger AG，巴塞尔
Background: Idiopathic Parkinson's disease (PD) and the Parkinsonian syndrome caused by manganese (Mn) poisoning are known to be indistinguishable in terms of symptoms. We thus suspect that many patients who have accumulated Mn in the body in daily life are diagnosed as having idiopathic PD. We examined the relationship between PD and blood levels of heavy metals, and the influence of intake from food in a general population. Methods: The subjects comprised PD patients and sex-and age-matched controls recruited from the outpatient clinic of Xiangfan No. 1 People's Hospital in Hubei, China, between 2006 and 2008. Information was obtained on previous eating habits before diagnosis of PD and other factors. Morning blood samples were collected before breakfast and were used to measure concentrations of metals. Results: The whole-blood Mn and serum iron (Fe) levels were significantly higher in PD patients than in controls. However, no differences in intake of each metal from food or experience of Mn poisoning were seen between the groups. Conclusions: In China, accumulation of Mn and Fe via unknown routes might be involved in the etiology of PD in the general population. Copyright (C) 2009 S. Karger AG, Basel