Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus
Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus
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DOI：
10.1002/acr.23531
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发表时间：
2018-11-01
影响因子：
4.7
通讯作者：
Brunner, Hermine I.
中科院分区：
文献类型：
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作者：
Holland, Michael J.;Beresford, Michael W.;Brunner, Hermine I.
ObjectiveMethodsTo describe the frequency and types of disease damage occurring with childhood-onset systemic lupus erythematosus (SLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity.Information for the SDI was prospectively collected from 1,048 childhood-onset SLE patients. For a subset of 559 patients, physician-rated damage severity measured by visual analog scale (MD VAS damage) was also available. Frequency of SDI items and the association between SDI summary scores and MD VAS damage were estimated. Finally, an international consensus conference, using nominal group technique, considered the SDI's capture of childhood-onset SLE-associated damage and its severity.ResultsConclusionAfter a mean disease duration of 3.8 years, 44.2% of patients (463 of 1,048) already had an SDI summary score >0 (maximum 14). The most common SDI items scored were proteinuria, scarring alopecia, and cognitive impairment. Although there was a moderately strong association between SDI summary scores and MD VAS damage (Spearman's r = 0.49, P < 0.0001) in patients with damage (SDI summary score >0), mixed-effects analysis showed that only 4 SDI items, each occurring in
