A reliable method for measurement and normalization of pediatric hippocampal volumes
A reliable method for measurement and normalization of pediatric hippocampal volumes
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DOI：
10.1203/00006450-200107000-00022
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发表时间：
2001-07-01
影响因子：
3.6
通讯作者：
Sarty, GE
中科院分区：
文献类型：
--
作者：
Obenaus, A;Yong-Hing, CJ;Sarty, GE
一个强大的标准化方法分割，量化和规范化的儿科海马体积使用磁共振成像。该方法将发现在时间过程中的测量海马体积的儿童患者谁患有颞叶癫痫，并进行了前瞻性测试，对6名对照患者（13-60个月的年龄）的应用。使用我们的分割方法获得的未归一化海马体积范围为3.85至6.35 mL，与先前发表的结果一致。分割方法的观察者间和观察者内变异性分别为13.3%和2.8%。测试了四种不同的体积归一化方法。正常化需要调整海马体积的年龄相关性增加。正常化的方法，似乎是最好的补偿生长相关的海马体积的变化是基于一个简单的估计颅内体积，这是第一次报告的一致和可靠的方法分割和正常化的大脑皮层从儿科患者，可用于研究儿童神经系统疾病的进展。
A robust standardized method for segmentation, quantification, and normalization of pediatric hippocampal volumes using magnetic resonance imaging is presented. The method will find application in time course measurements of hippocampal volumes in pediatric patients who suffer from temporal lobe epilepsy and was tested prospectively on six control patients (13-60 mo of age). The un-normalized hippocampal volumes obtained using our segmentation method ranged from 3.85 to 6.35 mL, in agreement with previously published results. Inter- and intraobserver variability of the segmentation method was determined to be 13.3% and 2.8%, respectively. Four different methods of volume normalization were tested. Normalization is required to adjust for age-related increases in hippocampal volume. The normalization approach that seemed to compensate best for growth-related hippocampal volume changes was based on a simple estimation of intracranial volumes, This is the first report of a consistent and reliable method for segmentation and normalization of hippocampi from pediatric patients that can be used to study the progression of neurologic diseases in children.