Strathprints Institutional Repository (2016) a Transient Translaminar Gabaergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal a Transient Translaminar Gabaergic Interneuron Circuit Connects Thalamocortical Recipient Layers in N
Strathprints Institutional Repository (2016) a Transient Translaminar Gabaergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal a Transient Translaminar Gabaergic Interneuron Circuit Connects Thalamocortical Recipient Layers in N
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通讯作者：
Marques-Smith;Andre Lyngholm;Daniel Kaufmann;Anna-Kristin Stacey;Jacqueline A And Hoerder-Suabedissen
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作者：
Marques-Smith;Andre Lyngholm;Daniel Kaufmann;Anna-Kristin Stacey;Jacqueline A And Hoerder-Suabedissen
Strathprints 旨在允许用户访问斯特拉斯克莱德大学的研究成果。除非稿件中另有明确说明，本网站论文的版权 © 和精神权利均由个人作者和/或其他版权所有者保留。请检查手稿以了解可能已应用的任何其他许可证的详细信息。您不得出于任何营利活动或任何商业利益而进一步分发该材料。您可以自由分发 URL (http://strathprints.strath.ac.uk/) 和本文内容用于研究或私人学习、教育或非营利目的，无需事先许可或收费。亮点 d 产后早期丘脑突触输入 L5b 生长抑素中间神经元 d L5b IN 和 L4 棘星状细胞之间短暂的相互连接 d 感觉活动是过渡到局部 L4 GABA 能回路所必需的 d 对早期局部 IN 突触的分子偏向延迟了 SSN 的丘脑神经支配 简述 Marques-Smith 等人。识别出参与初级体感皮层丘脑皮层整合的短暂、出生后早期 GABA 能中间神经元回路。感觉和分子线索的扰动改变了该回路的时间动态，从而改变了丘脑皮质传入输入的成熟。摘要 GABA 能活动被认为会影响新皮质感觉回路的发育。然而，局部层 (L)4 回路的出生后成熟较晚，表明新生丘脑皮质网络中存在 GABA 能控制的替代来源。我们发现，L5b 生长抑素 (SST) 阳性中间神经元群体接收早期丘脑突触输入，并使用激光扫描光刺激，识别出这些细胞和 L4 刺星状细胞 (SSN) 之间的早期瞬态电路，该电路在 L4 关键期结束时消失。感觉扰动破坏了向局部 GABA 能回路的转变，表明 SSN 的跨层控制和局部控制之间存在联系。 SST+中间神经元的条件性沉默或相反地通过1型神经调节蛋白1的过度表达使电路偏向局部抑制，导致突变体中早期L5b GABA能输入的缺失，并延迟了SSN的丘脑神经支配。这些数据确定了 L5b SST+ 中间神经元在控制产后早期新皮质 SSN 中的作用。
Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (http://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge. Highlights d Early postnatal thalamic synaptic input onto L5b somatostatin interneurons d Transient reciprocal connectivity between L5b INs and L4 spiny stellate cells d Sensory activity is required for the transition to a local L4 GABAergic circuit d Molecular bias toward early local IN synapses delays thalamic innervation of SSNs In Brief Marques-Smith et al. identify a transient, early postnatal GABAergic interneuron circuit involved in thalamocortical integration in primary somatosensory cortex. Perturbation of sensory and molecular cues alters the temporal dynamics of this circuit and thereby maturation of thalamocortical afferent input. SUMMARY GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thala-mocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stel-lates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overex-pression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.