THE NATURAL-HISTORY OF PEANUT ALLERGY
THE NATURAL-HISTORY OF PEANUT ALLERGY
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DOI：
10.1016/0091-6749(89)90103-6
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发表时间：
1989-05-01
影响因子：
14.2
通讯作者：
ATKINS, FM
中科院分区：
文献类型：
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作者：
BOCK, SA;ATKINS, FM
在1973至1985年间，114名2至14岁的儿童接受了花生的双盲、安慰剂对照食物挑战(DBPCFC)。46名儿童中有32名儿童出现了DBPCFC对花生的症状，纳入了这项纵向评估。32名受试者在DBPCFC对花生呈阳性后2~14年进行接触。在最初的评估时，所有32名受试者都表现出花生刺激性皮肤试验阳性。16名受试者在接触前一年因意外摄入花生而出现症状。8名受试者在接触前超过1年但不到5年的时间内对意外摄入有反应。8名受试者自最初评估以来完全避免吃花生，DBPCFC呈阳性。没有一位受试者被证明已经“长大”，失去了他们的花生反应能力。所有接受测试的受试者对花生提取物的皮肤穿刺性试验继续有皮肤反应性。对花生敏感的患者即使在多年后也会失去临床反应性，这似乎是不常见的。此外，还收集了有关对其他豆类和其他(非豆类)坚果反应的数据。只有两名DBPCFC患者对花生有反应，DBPCFC对大豆或豌豆(各一例)有反应。对花生的DBPCFC呈阳性的受试者对非豆类坚果没有反应。
Between 1973 and 1985, 114 children, aged 2 to 14 years, underwent double-blind, placebo-controlled, food challenge (DBPCFC) to peanut. Thirty-two of 46 children with symptoms produced by DBPCFC to peanut were included in this longitudinal evaluation. Contact was made with the 32 subjects 2 to 14 years after their positive DBPCFC to peanut. All 32 subjects had exhibited a positive puncture skin test to peanut at the time of the original evaluation. Sixteen subjects had experienced symptoms caused by accidental peanut ingestion in the year before contact. Eight subjects had reacted to accidental ingestion in more than 1 year but less than 5 years before contact. Eight subjects had completely avoided peanut since the original evaluation and positive DBPCFC. No subjects could be demonstrated to have "outgrown" their peanut reactivity. All subjects tested continued to have skin reactivity to a puncture skin test with peanut extract. It appears uncommon for peanut-sensitive patients to lose their clinical reactivity, even after many years have elapsed. In addition, data were collected concerning reactions to other legumes and other (nonlegume) nuts. Only two patients with DBPCFC to peanut reacted on DBPCFC to soy or pea (one each). None of the subjects with a positive DBPCFC to peanut reacted to nonlegume nuts.