Trends in protein evolution inferred from sequence and structure analysis
Trends in protein evolution inferred from sequence and structure analysis
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DOI：
10.1016/s0959-440x(02)00334-2
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发表时间：
2002-06-01
影响因子：
6.8
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Aravind, L;Mazumder, R;Koonin, EV
比较基因组学、蛋白质结构测定以及蛋白质序列和结构的深入比较方面的互补发展使人们更好地了解了蛋白质结构域出现和多样化的普遍趋势。对参与关键细胞功能的不同类别蛋白质之间的深层关系的研究表明，在原始的、核酶主导的RNA世界中，进化出了一组不同的蛋白质结构域。
Complementary developments in comparative genomics, protein structure determination and in-depth comparison of protein sequences and structures have provided a better understanding of the prevailing trends in the emergence and diversification of protein domains. The investigation of deep relationships among different classes of proteins involved in key cellular functions, such as nucleic acid polymerases and other nucleotide-dependent enzymes, indicates that a substantial set of diverse protein domains evolved within the primordial, ribozyme-dominated RNA world.