A dynamic phantom brain model for near-infrared spectroscopy.
A dynamic phantom brain model for near-infrared spectroscopy.
复制标题
近红外光谱的动态幻脑模型。
DOI：
10.1088/0031-9155/40/12/006
复制
发表时间：
1995
影响因子：
3.5
通讯作者：
Chance,B
中科院分区：
文献类型：
--
作者：
Kurth,CD;Liu,H;Thayer,WS;Chance,B
描述了用于测试近红外光谱（NIRS）仪器的新生儿大脑体外模型的结构、流体动力学和光学特性。脑模型是一个固体塑料结构，包含一个血管网络，血流在封闭回路中与o2， n2和CO 2平衡。灌注液的氧合状态和血红蛋白浓度可以用共氧仪进行调节和测量，提供了一种方法来比较近红外测量的氧、脱氧和总血红蛋白浓度和血红蛋白o2，直接使用经过验证的标准方法。流体动力学实验表明，随着时间的推移，模型血管系统保持稳定，溶血最小。模型的光学特性在670 ~ 850 nm范围内进行了时间分辨和连续波近红外光谱表征，灌注饱和度在0 ~ 100%范围内变化。用类似的方法测定了新生仔猪脑的光学特性。该模型与仔猪脑在吸收系数、散射系数和光路长度方面均无显著差异，表明该模型在较宽的氧合状态下光学模拟了仔猪脑。这些结果证明了这种动态幻脑在测试NIPS仪器的准确性和可靠性方面的潜在效用。
Describes the construction, fluid dynamics and optical properties of an in vitro model of the neonatal brain for testing near-infrared spectroscopy (NIRS) instruments. The brain model is a solid plastic structure containing a vascular network perfused with blood equilibrated with O 2, N 2 and CO 2 in a closed circuit. The oxygenation state and haemoglobin concentration of the perfusate can be regulated and measured with a co-oximeter, providing a means to compare NIRS measurements of oxy-, deoxy-and total haemoglobin concentrations and haemoglobin O 2 directly with a validated standard method. Fluid dynamic experiments revealed that the models vasculature remains stable over time with minimal haemolysis. The models optical properties were characterized by time-resolved and continuous wave NIRS between 670 and 850 nm as perfusate saturation was varied in the range 0-100%. Optical properties of the neonatal piglet brain were also determined by similar methods. No significant differences were found between the model and piglet brain in absorption coefficients, reduced scattering coefficients and optical pathlengths, indicating that the model optically simulates the piglet brain over a wide range of oxygenation states. These results demonstrate the potential utility of this dynamic phantom brain for testing NIPS instruments for accuracy and reliability.