Replication stress in Mammalian cells and its consequences for mitosis.
Replication stress in Mammalian cells and its consequences for mitosis.
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DOI：
10.3390/genes6020267
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发表时间：
2015-05-22
期刊：
影响因子：
3.5
通讯作者：
Lopez BS
中科院分区：
文献类型：
--
作者：
Gelot C;Magdalou I;Lopez BS
将遗传信息忠实地传递到子细胞是维持基因组稳定的核心，并依赖于每个细胞周期中遗传物质的准确和完整复制。然而，基因组经常暴露在内源和外源压力下，这可能会阻碍复制的进程。这种复制压力可能是癌症或启动衰老的早期原因。复制胁迫主要发生在S期，导致有丝分裂过程中的后果，危及染色体分离，进而影响基因组的稳定性。在G1期的子代细胞中可以检测到复制应激的痕迹。有丝分裂的改变有两种类型：1)局部改变，对应于断裂、重排、缠绕的DNA分子或局限于复制功能障碍区域的未分离的姐妹染色单体；2)中心体扩增导致的全基因组染色体分离(尽管中心体不含DNA)，将局部复制压力放大到整个基因组。在这里，我们讨论了复制扰动的内生原因、复制分叉重新启动的机制以及对有丝分裂、染色体分离和基因组稳定性的影响。
The faithful transmission of genetic information to daughter cells is central to maintaining genomic stability and relies on the accurate and complete duplication of genetic material during each cell cycle. However, the genome is routinely exposed to endogenous and exogenous stresses that can impede the progression of replication. Such replication stress can be an early cause of cancer or initiate senescence. Replication stress, which primarily occurs during S phase, results in consequences during mitosis, jeopardizing chromosome segregation and, in turn, genomic stability. The traces of replication stress can be detected in the daughter cells during G1 phase. Alterations in mitosis occur in two types: 1) local alterations that correspond to breaks, rearrangements, intertwined DNA molecules or non-separated sister chromatids that are confined to the region of the replication dysfunction; 2) genome-wide chromosome segregation resulting from centrosome amplification (although centrosomes do not contain DNA), which amplifies the local replication stress to the entire genome. Here, we discuss the endogenous causes of replication perturbations, the mechanisms of replication fork restart and the consequences for mitosis, chromosome segregation and genomic stability.
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影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
影响因子：
64.8
作者：
Burrell RA;McClelland SE;Endesfelder D;Groth P;Weller MC;Shaikh N;Domingo E;Kanu N;Dewhurst SM;Gronroos E;Chew SK;Rowan AJ;Schenk A;Sheffer M;Howell M;Kschischo M;Behrens A;Helleday T;Bartek J;Tomlinson IP;Swanton C
通讯作者：
Swanton C
影响因子：
64.5
作者：
Barlow JH;Faryabi RB;Callén E;Wong N;Malhowski A;Chen HT;Gutierrez-Cruz G;Sun HW;McKinnon P;Wright G;Casellas R;Robbiani DF;Staudt L;Fernandez-Capetillo O;Nussenzweig A
通讯作者：
Nussenzweig A
DOI：
10.4161/15384101.2014.977067
发表时间：
2015
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Benada J;Burdová K;Lidak T;von Morgen P;Macurek L
通讯作者：
Macurek L
影响因子：
16
作者：
Bothmer A;Robbiani DF;Di Virgilio M;Bunting SF;Klein IA;Feldhahn N;Barlow J;Chen HT;Bosque D;Callen E;Nussenzweig A;Nussenzweig MC
通讯作者：
Nussenzweig MC