Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
Lateral Inhibition in the Vertebrate Retina: The Case of the Missing Neurotransmitter.
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DOI：
10.1371/journal.pbio.1002322
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发表时间：
2015-12
期刊：
影响因子：
9.8
通讯作者：
Davenport CM
中科院分区：
文献类型：
--
作者：
Kramer RH;Davenport CM
视网膜第一个突触的横向抑制对于视觉感知、增强图像对比度、颜色辨别和光适应很重要。尽管经过了数十年的研究，从水平细胞到产生侧抑制的光感受器的反馈信号仍然不确定。 GABA、质子或触觉机制都被认为是反馈的主要介质。然而，水平细胞突触的倒锥体的复杂性使得反馈信号的身份成为一个未解之谜。我们令人印象深刻的视觉取决于视觉系统中第一个突触处水平细胞到感光器的负反馈，但负责调节这种反馈的实际信号仍然神秘。本文将对嫌疑人进行调查。
Lateral inhibition at the first synapse in the retina is important for visual perception, enhancing image contrast, color discrimination, and light adaptation. Despite decades of research, the feedback signal from horizontal cells to photoreceptors that generates lateral inhibition remains uncertain. GABA, protons, or an ephaptic mechanism have all been suggested as the primary mediator of feedback. However, the complexity of the reciprocal cone to horizontal cell synapse has left the identity of the feedback signal an unsolved mystery. Our impressive sense of sight depends on negative feedback from horizontal cells to photoreceptors at the first synapse in the visual system, but the actual signal responsible for mediating this feedback remains mysterious. This article investigates the suspects.