Conflict-sensitive neurons gate interocular suppression in human visual cortex.
Conflict-sensitive neurons gate interocular suppression in human visual cortex.
复制标题
冲突敏感的神经元门在人类视觉皮层中的眼内抑制。
DOI：
10.1038/s41598-018-19809-w
复制
发表时间：
2018-01-19
影响因子：
4.6
通讯作者：
Engel SA
中科院分区：
文献类型：
--
作者：
Katyal S;Vergeer M;He S;He B;Engel SA
神经抑制在皮层功能中起重要作用，包括感觉、记忆和运动系统。然而，人们对它的了解相对较少。当两只眼睛看到相互冲突的图像时，就会出现一个典型的例子。这些图像会争夺意识，通常会被强烈抑制。解决这种眼间冲突的机制尚不清楚。抑制可能仅仅来自对每只眼睛都有反应的神经元之间的“赢者通吃”竞争。或者，抑制也可能依赖于神经元检测眼间冲突。在这里，我们为后者提供了人类视觉皮层的生理证据：抑制依赖于冲突敏感神经元。我们记录稳态视觉诱发电位（SSVEP），并采用选择性适应逻辑。在互调频率下，SSVEP的反应幅度随着刺激中眼间冲突的增加而增强，表明存在对冲突有反应的神经元。关键是，对冲突的适应既降低了这种SSVEP效应，又增加了产生知觉抑制所需的冲突量。对这些结果最简单的解释是，人类皮层中存在眼间冲突敏感神经元：适应可能会降低这些神经元的反应性，从而提高产生知觉抑制所需的冲突量。类似的机制也可用于解决其他类型的感知冲突。
Neural suppression plays an important role in cortical function, including sensory, memory, and motor systems. It remains, however, relatively poorly understood. A paradigmatic case arises when conflicting images are presented to the two eyes. These images can compete for awareness, and one is usually strongly suppressed. The mechanisms that resolve such interocular conflict remain unclear. Suppression could arise solely from “winner-take-all” competition between neurons responsive to each eye. Alternatively, suppression could also depend upon neurons detecting interocular conflict. Here, we provide physiological evidence in human visual cortex for the latter: suppression depends upon conflict-sensitive neurons. We recorded steady-state visual evoked potentials (SSVEP), and used the logic of selective adaptation. The amplitude of SSVEP responses at intermodulation frequencies strengthened as interocular conflict in the stimulus increased, suggesting the presence of neurons responsive to conflict. Critically, adaptation to conflict both reduced this SSVEP effect, and increased the amount of conflict needed to produce perceptual suppression. The simplest account of these results is that interocular-conflict-sensitive neurons exist in human cortex: adaptation likely reduced the responsiveness of these neurons which in turn raised the amount of conflict required to produce perceptual suppression. Similar mechanisms may be used to resolve other varieties of perceptual conflict.
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DOI：
10.1016/j.cub.2017.03.074
发表时间：
2017-05-22
期刊：
Current biology : CB
影响因子：
--
作者：
Goncalves NR;Welchman AE
通讯作者：
Welchman AE
影响因子：
25
作者：
Polonsky, A;Blake, R;Heeger, DJ
通讯作者：
Heeger, DJ
影响因子：
2.9
作者：
Dayan, P
通讯作者：
Dayan, P
影响因子：
2.5
作者：
OHZAWA, I;FREEMAN, RD
通讯作者：
FREEMAN, RD
影响因子：
1.7
作者：
Carter, OL;Pettigrew, JD
通讯作者：
Pettigrew, JD